David Mouriño Gerente de Licenciamiento Digital Mexico Inducción a: Author Academy

Springer Author Academy

1.Selección de Journal 2.Estructura del manuscrito 3.Objetivo de la revista 4.Escritura efectiva 5.Cartas de presentación 6.Revisión por pares En esta inducción…

Selección de Journal Sección 1

Edanz: Principales dificultades durante la preparación del manuscrito n = 333 published non-native English authors Choosing a journal Expressing thoughts clearly in English Understanding the author guidelines Formatting according to the guidelines % 23.7% 21.9% 18.9% Los autores tienen dificultades para elegir las revistas

Selección de Journal Cuándo Eligirá el journal en el que publicará: – Despúes de que ha decidido que tiene suficientes resultados como para publicar – Despúes de que ha decidido que tan alto y amplio será el impacto de su publicación – Despúes y de que ha decidido que tan relevantes son los resultados – Antes de escribir el título, resumen e introducción del artículo

Selección de Journal Tenga en cuenta los diferentes factores de cada revista Objetivos y alcance Número de lectores Acceso abierto Indexación ¿Qué factor es más importante para usted? Frecuencia de publicación Factor de impacto Varies by field

Selección de Journal Eligiendo un Journal Honestamente evalue la importancia de su investigación Significado Objetivos y alcance / impacto

Selección de Journal Evaluación ¿Qué tan nuevos son sus descubrimientos? Autenticidad ¿Qué tan relevantes son? Relevancia ¿Qué tanto se puede aplicar al mundo real? Interés

Escritura efectiva Tipos de publicaciones científico-técnicas Artículo en revistas (journal paper) – journal (científico) / magazine (divulgación) Ponencia – Principal (keynote) –invitada- – Ponencia (conference paper) –invitada- Comunicación (contributed paper) –libre versión escrita versión para presentar Patente – Contrato inventor-Estado que permite fabricar algo en exclusiva durante 20 años (luego pasa al dominio público) Informe – Memoria (proyecto) – Libro blanco (informe oficial de situación, exhaustivo) – Libro verde (libro de consulta, con propuestas)

Escritura efectiva ¿Dónde publicar?

Selección de Journal Insert your proposed abstract El Journal Selector ayuda a elegir la publicacion más adecuada Journal Selector –

Selección de Journal Journals recomendados Filtrar por: Factor de impacto Frecuencia de publicación Acceso Abierto Filtrar por: Factor de impacto Frecuencia de publicación Acceso Abierto Journal Selector –

Selección de Journal Términos semánticos que encajan Journals FI, Objetivos, alcance y frecuencia Artículos similares ¿Se han publicado artículos similares recientemente? ¿Ha citado algunos de estos artículos? Journal Selector –

Selección de Journal Visite el sitio del journal

Selección de Journal Tips para identificar la revista más adecuada S Identica los intereses del editor de la revista Identifica los intereses de los lectores Editoriales Artículos en revisión Fascículos especiales Editoriales Artículos en revisión Fascículos especiales Más vistos Más citados Más vistos Más citados Identifica los intereses del editor de la revista y de los lectores en cada publicación

Estructura del Manuscrito Sección 2

Coverage and Staffing Plan Estructura del Manuscrito Puntos importantes Resuma las principales conclusiones Palabras clave Menos de 20 palabras Resuma las principales conclusiones Palabras clave Menos de 20 palabras Evitar Preguntas Abreviaciones “New” o “novel” Preguntas Abreviaciones “New” o “novel” Títulos efectivos El título debe ser conciso y resumir su hallazgos clave

Coverage and Staffing Plan Estructura del Manuscrito Resúmen / Abstract Es la primera impresión de su documento Importancia de sus resultados Validez de sus conclusiones Relevancia de sus objetivos Juzgue su estilo de escritura Probablemente sea la única parte que sea leída

Coverage and Staffing Plan Estructura del Manuscrito Secciones del Resumen Objetivos Antecedentes Métodos Resultados Conclusión ¿Porque se hizo el estudio?(20%) Hipótesis (10%) Tecnicas (10%) Hallazgos más importantes(40%) Conclusiones/implicaciones (20%) Síntesis concisa de su investigación

Resúmenes Unstructured abstract Conclusión Thus, coordinated rotational movement is a unique mechanophysical process observed during normal 3D morphogenesis that regulates laminin matrix assembly and is lost in cancer-derived epithelial cells. Resultados We report that in addition to actively maintaining apicobasal polarity, the structures underwent rotational motions at rates of 15–20 μm/h and the structures rotated 360° every 4 h during the early phase of morphogenesis. Rotational motion was independent of the cell cycle, but was blocked by loss of the epithelial polarity proteins Scribble or Pard3, or by inhibition of dynein-based microtubule motors. Interestingly, none of the structures derived from human cancer underwent rotational motion. We found a direct relationship between rotational motion and assembly of endogenous basement membrane matrix around the 3D structures, and that structures that failed to rotate were defective in weaving exogenous laminin matrix. Dissolution of basement membrane around mature, nonrotating acini restored rotational movement and the ability to assemble exogenous laminin. Métodos We performed multidimensional live-cell imaging analysis to track the morphogenetic process starting from a single cell to the development of a multicellular, spherical structure composed of polarized epithelial cells surrounding a hollow lumen. Antecedentes Our understanding of the mechanisms by which ducts and lobules develop is derived from model organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells undergo morphogenesis to form multicellular spheres with a hollow central lumen. However, the mechanophysical properties associated with epithelial morphogenesis are poorly understood. Wang et al. PNAS. 2013; 110: 163‒168. Escriba su reseña en secciones Escriba su reseña en secciones

Resúmenes Escriba su Resumen Our understanding of the mechanisms by which ducts and lobules develop is derived from model organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells undergo morphogenesis to form multicellular spheres with a hollow central lumen. However, the mechanophysical properties associated with epithelial morphogenesis are poorly understood. We performed multidimensional live-cell imaging analysis to track the morphogenetic process starting from a single cell to the development of a multicellular, spherical structure composed of polarized epithelial cells surrounding a hollow lumen. We report that in addition to actively maintaining apicobasal polarity, the structures underwent rotational motions at rates of 15–20 μm/h and the structures rotated 360° every 4 h during the early phase of morphogenesis. Rotational motion was independent of the cell cycle, but was blocked by loss of the epithelial polarity proteins Scribble or Pard3, or by inhibition of dynein-based microtubule motors. Interestingly, none of the structures derived from human cancer underwent rotational motion. We found a direct relationship between rotational motion and assembly of endogenous basement membrane matrix around the 3D structures, and that structures that failed to rotate were defective in weaving exogenous laminin matrix. Dissolution of basement membrane around mature, nonrotating acini restored rotational movement and the ability to assemble exogenous laminin. Thus, coordinated rotational movement is a unique mechanophysical process observed during normal 3D morphogenesis that regulates laminin matrix assembly and is lost in cancer-derived epithelial cells. Wang et al. PNAS. 2013; 110: 163‒168.

Resúmenes Our understanding of the mechanisms by which ducts and lobules develop is derived from model organisms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells undergo morphogenesis to form multicellular spheres with a hollow central lumen. However, the mechanophysical properties associated with epithelial morphogenesis are poorly understood. We performed multidimensional live-cell imaging analysis to track the morphogenetic process starting from a single cell to the development of a multicellular, spherical structure composed of polarized epithelial cells surrounding a hollow lumen. We report that in addition to actively maintaining apicobasal polarity, the structures underwent rotational motions at rates of 15–20 μm/h and the structures rotated 360° every 4 h during the early phase of morphogenesis. Rotational motion was independent of the cell cycle, but was blocked by loss of the epithelial polarity proteins Scribble or Pard3, or by inhibition of dynein-based microtubule motors. Interestingly, none of the structures derived from human cancer underwent rotational motion. We found a direct relationship between rotational motion and assembly of endogenous basement membrane matrix around the 3D structures, and that structures that failed to rotate were defective in weaving exogenous laminin matrix. Dissolution of basement membrane around mature, nonrotating acini restored rotational movement and the ability to assemble exogenous laminin. Thus, coordinated rotational movement is a unique mechanophysical process observed during normal 3D morphogenesis that regulates laminin matrix assembly and is lost in cancer-derived epithelial cells. Conclusiones Resultados Métodos Antecedentes Wang et al. PNAS. 2013; 110: 163‒168. Escriba su Resumen

Coverage and Staffing Plan Estructura del Manuscrito Introduction Introducción General Objetivos específicos Objetivos Estado del arte del campo Problemas en el campo Introduzca su tema de manera lógica de lo general a lo específico Introduzca su tema de manera lógica de lo general a lo específico

Coverage and Staffing Plan Estructura del Manuscrito Métodos Cómo se hizo Métodos generales Técnicas específicas (controles de discusión) Métodos generales Técnicas específicas (controles de discusión) Análisis de datos Métodos de cuantificación Pruebas estadísticas Análisis de datos Métodos de cuantificación Pruebas estadísticas Lo que fue utilizado Muestras o materiales Cómo fue analizado Sus métodos reflejan su diseño experimental

Coverage and Staffing Plan Estructura del Manuscrito Resultados 1.Observación inicial 2.Caracterización 3.Aplicación 1.Observación inicial 2.Caracterización 3.Aplicación Cada subsección corresponde a una figura Cada subsección corresponde a una figura Qué has encontrado, no lo que significa Presentación lógica Subsecciones Descripción fáctica Presente sus resultados en un orden lógico

Coverage and Staffing Plan Estructura del Manuscrito Imágenes Presentan muchos datos de forma rápida y eficiente Que sean sencillas: recuadros separados si es necesario Etiquetas claras y leyendas de las figuras Por lo general es lo primer que los lectores ven Figuras, gráficos y tablas

Coverage and Staffing Plan Estructura del Manuscrito Discusión Comienzo Medio Final Resúmen de hallazgos clave Estado de la conclusión principal Resúmen de hallazgos clave Estado de la conclusión principal Replantear la conclusión principal Aplicaciones/implicaciones Proponer un futuro trabajo Replantear la conclusión principal Aplicaciones/implicaciones Proponer un futuro trabajo Interpretar los resultados en el contexto de otros estudios Describir limitaciones Interpretar los resultados en el contexto de otros estudios Describir limitaciones

Coverage and Staffing Plan Estructura del Manuscrito Referencias Cite todas las declaraciones de los trabajos publicados anteriormente Utilice software de gestión de referencias: EndNote, Papers, RefWorks, Mendeley Utilice software de gestión de referencias: EndNote, Papers, RefWorks, Mendeley Cite ampliemente los diferentes grupos en su campo

Coverage and Staffing Plan Estructura del Manuscrito Vincule sus ideas Antecedentes generales Objectivos Metodología Resultados y cifras Resumen de los resultados Implicaciones para el campo Relevancia del hallazgo Lagunas de conocimiento Enlace lógicamente sus ideas en su investigación Estado del arte Introducción Métodos Resultados Discusión

Coverage and Staffing Plan Estructura del Manuscrito Vincule sus ideas New ways to treat or prevent lung cancer are therefore needed. New ways to treat or prevent lung cancer are therefore needed. This study explored the hypothesis that inhibition of TNKS…would inhibit lung cancer growth… Pharmacological or genetic inhibition of TNKS1 and TNKS2…reduces lung cancer proliferation... Problema Objetivos Conclusión Discusión Introducción Busch et al. BMC Cancer. 2012;13:211.

Objetivo de la revista Sección 3

Customer Service Target the journal Chlorophyll is present in many plant organs, including immature fruit where it is usually degraded during ripening. Mature green kiwifruit (Actinidia deliciosa) are an exception, with high concentrations of chlorophyll remaining in the fruit flesh. In gold-fleshed kiwifruit (A. chinensis), chlorophyll is degraded to colourless catabolites upon fruit ripening, leaving yellow carotenoids visible. We have identified candidate genes for the control of chlorophyll degradation… Pilkington et al. Planta. 2012; 236: 1615−1628. The control of chlorophyll levels in maturing kiwifruit Enfoque de la revista Planta

Customer Service Target the journal Chlorophyll is present in many plant organs, including immature fruit where it is usually degraded during ripening. Mature green kiwifruit (Actinidia deliciosa) are an exception, with high concentrations of chlorophyll remaining in the fruit flesh. In gold-fleshed kiwifruit (A. chinensis), chlorophyll is degraded to colourless catabolites upon fruit ripening, leaving yellow carotenoids visible. We have identified candidate genes for the control of chlorophyll degradation… Pilkington et al. Planta. 2012; 236: 1615−1628. The control of chlorophyll levels in maturing kiwifruit De amplio interés Planta Enfoque de la revista

Customer Service Target the journal Chlorophyll is present in many plant organs, including immature fruit where it is usually degraded during ripening. Mature green kiwifruit (Actinidia deliciosa) are an exception, with high concentrations of chlorophyll remaining in the fruit flesh. In gold-fleshed kiwifruit (A. chinensis), chlorophyll is degraded to colourless catabolites upon fruit ripening, leaving yellow carotenoids visible. We have identified candidate genes for the control of chlorophyll degradation… Pilkington et al. Planta. 2012; 236: 1615−1628. The control of chlorophyll levels in maturing kiwifruit De amplio interés Publicación de amplio enfoque Planta

Customer Service Target the journal Traditional weed management, such as tillage and irrigation, has led to an enhanced maintenance of wetland plant species in fallow paddy fields. Recent herbicide usage and improvements in irrigation and drainage systems however have caused habitat loss of these species, especially in fields on open lowlands… Effects of tillage and irrigation on the occurrence and establishment of native wetland plant species in fallow paddy fields Publicación de enfoque específico Paddy and Water Development Takanose et al. Paddy Water Environ. 2013; 11: 1−4.

Customer Service Target the journal Traditional weed management, such as tillage and irrigation, has led to an enhanced maintenance of wetland plant species in fallow paddy fields. Recent herbicide usage and improvements in irrigation and drainage systems however have caused habitat loss of these species, especially in fields on open lowlands… Effects of tillage and irrigation on the occurrence and establishment of native wetland plant species in fallow paddy fields Paddy and Water Development Takanose et al. Paddy Water Environ. 2013; 11: 1−4. Keywords from the Aims and Scope Publicación de enfoque específico

Escritura efectiva Sección 4

Escritura efectiva Alta legibilidad Su lector debería… Entender su lógica de manera inmediata No tendría que leer despacio Leer sólo una vez

Escritura efectiva 1. Frases cortas 30 palabras The largest company, a Mexican corporation founded in 1916 outside of Puebla by Miguel Hernández, was considered to be a model in the development of modern employee conditions by economists.

Escritura efectiva Frases cortas 30 palabras The largest company, a Mexican corporation founded in 1916 outside of Puebla by Miguel Hernández, was considered to be a model in the development of modern employee conditions by economists.

Escritura efectiva Frases cortas Economists considered the largest company to be a model in the development of modern employee conditions. This company was a Mexican corporation founded in 1916 outside of Puebla by Miguel Hernández. 16 words 15 words Utilice sólo una idea por oracion 15–20 palabras Utilice sólo una idea por oracion 15–20 palabras

Escritura efectiva 2. Voz activa Las oraciones escritas en voz activa son: simples directas Claras Fáciles de leer The mechanisms regulating tumor growth were investigated. Pasiva We investigated the mechanisms regulating tumor growth. Activa Utilice la voz activa para ser más directos

Escritura efectiva Se prefiere la voz activa “Use the active voice when it is less wordy and more direct than the passive”. (3 rd ed., pg. 42) “Use the active voice rather than the passive voice…”. “Use the active voice rather than the passive voice…”. “As a matter of style, passive voice is typically, but not always, inferior to active voice”. (15 th ed., pg. 177) “In general, authors should use the active voice…”. (10 th ed., pg. 320) ACS Style Guide APA Style Chicago Style Guide AMA Manual of Style

Escritura efectiva 3. Posición de tensión Los lectores se centran en el final de la oración para identificar lo que es importante 1.You deserve a raise, but the budget is tight. ¿Qué oración sugiere que conseguirá un aumento de sueldo? 2.The budget is tight, but you deserve a raise.

Escritura efectiva Posición de tensión The budget is tight, but you deserve a raise. Your salary will increase at the beginning of next year. La posición de tensión debe introducir el tema de la siguiente oracion La posición de tensión debe introducir el tema de la siguiente oracion

Escritura efectiva The budget is tight, but you deserve a raise. Your salary will increase at the beginning of next year. La posición de tensión debe introducir el tema de la siguiente oración La posición de tensión debe introducir el tema de la siguiente oración Posición de tensión Posición de estrés

Escritura efectiva Posición de tensión The budget is tight, but you deserve a raise. Your salary will increase at the beginning of next year. La posición de tensión debe introducir el tema de la siguiente oración La posición de tensión debe introducir el tema de la siguiente oración Posición de tensión Posición del tema La posición del tema identifica de qué trata la oración

Escritura efectiva 4. Posición del tema The patient went to the hospital to see a gastroenterologist. The doctor then performed a series of diagnostic tests. The results showed the patient suffered from a bacterial infection. Antibiotics were prescribed to treat the infection before the patient developed an ulcer. idea Tema enlace oración Esta forma es mucho más común en inglés que en español Simpson JM. J Second Lang Writ. 2000; 9: 293–309.

Escritura efectiva Estructura del manuscrito Lung cancer is the leading cause of cancer mortality for men and women. Despite smoking prevention and cessation programs… …New ways to treat or prevent lung cancer are therefore needed. One potential therapeutic target for lung cancer is the Wnt signaling pathway. The canonical Wnt signaling pathway in mammals consists of a… Busch et al. BMC Cancer. 2012; 13: 211.

Escritura efectiva Lung cancer is the leading cause of cancer mortality for men and women. Despite smoking prevention and cessation programs… …New ways to treat or prevent lung cancer are therefore needed. One potential therapeutic target for lung cancer is the Wnt signaling pathway. The canonical Wnt signaling pathway in mammals consists of a… Busch et al. BMC Cancer. 2012; 13: 211. Oración temática Estructura del manuscrito

Escritura efectiva Lung cancer is the leading cause of cancer mortality for men and women. Despite smoking prevention and cessation programs… …New ways to treat or prevent lung cancer are therefore needed. One potential therapeutic target for lung cancer is the Wnt signaling pathway. The canonical Wnt signaling pathway in mammals consists of a… Busch et al. BMC Cancer. 2012; 13: 211. Oración temática Stress sentence Estructura del manuscrito

Escritura efectiva Lung cancer is the leading cause of cancer mortality for men and women. Despite smoking prevention and cessation programs… …New ways to treat or prevent lung cancer are therefore needed. One potential therapeutic target for lung cancer is the Wnt signaling pathway. The canonical Wnt signaling pathway in mammals consists of a… Busch et al. BMC Cancer. 2012; 13: 211. Oración temática Stress sentence Utilice la posicion de tensión y tema en su escrito de manera lógica al presentar la información Estructura del manuscrito

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Cartas de presentación Sección 5

Coverage and Staffing Plan Cartas de presentación Resumen: Primera impresión para lectores Resumen: Primera impresión para lectores Las cartas de presentación son la primer impresión del editor de la revista Significado Relevancia Significado Relevancia Nivel de inglés ¿Es interesante para los lectores? ¿Es importante su trabajo?

Coverage and Staffing Plan Cartas de presentación Dear Dr Graeber, Please find enclosed our manuscript entitled “Amyloid-like inclusions in the brains of Huntington’s disease patients”, by McGowan et al., which we would like to submit for publication as a Research Paper in Neurogenetics. Recent immunohistochemical studies have revealed the presence of neuronal inclusions containing an N-terminal portion of the mutant huntingtin protein and ubiquitin in the brain tissues of Huntington’s disease (HD) patients; however, the role of these inclusions in the disease process has remained unclear. One suspected disease-causing mechanism in Huntington’s disease and other polyglutamine disorders is the potential for the mutant protein to undergo a conformational change to a more stable anti-parallel β -sheet structure… To confirm if the immunohistochemically observed huntingtin- and ubiquitin-containing inclusions display amyloid features, we performed Congo red staining and both polarizing and confocal microscopy on post-mortem human brain tissues obtained from five HD patients, two AD patients, and two normal controls. Congo red staining revealed a small number of amyloid-like inclusions showing green birefringence by polarized microscopy, in a variety of cortical regions.... ….detected inclusions observed in parallel sections, suggesting that only a relatively small proportion of inclusions in HD adopt an amyloid-like structure. We believe our findings will be of particular interest to the readership of Neurogenetics, which includes researchers and clinicians studying the genetic and molecular mechanisms underlying neurodegenerative diseases. Therefore, we feel that your journal provides the most suitable platform for the dissemination of our work to the research community. Antecedentes de la investigación ¿Qué se hizo y que se encontro? Razones de interés para los lectores de la revista Una buena carta de presentación We would also like to suggest the following reviewers for our manuscript… Nombre del editor Título del manuscrito Tipo de publicación Revisores recomendados “Hay que tener” declaraciones

Coverage and Staffing Plan Cartas de presentación Ciertas declaraciones que “Debe tener” No enviado a otras revistas Fuentes de financiamiento L os autores están de acuerdo con documento/revista Original y no publicado No existen conflictos de interés Contibuciones de autoría

Coverage and Staffing Plan Cartas de presentación Recomendando evaluadores “When submitting your paper, you must provide the names, affiliations, and valid addresses of five (5) reviewers. If you do not do so, your paper will be returned, unreviewed.” “Authors are requested to provide the names and full addresses (including address) of up to four potential referees…” Verifique las directrices de la revista para determinar cuántos revisores se recomiendan

Coverage and Staffing Plan Cartas de presentación Recomendando evaluadores ¿Dónde encontrarlos? De sus lecturas / referencias, creación de redes en las conferencias ¿De alto nivel? Trate que los investigadores sean de nivel medio ¿Qué evitar? Colaboradores (últimos 5 años), Investigadores de la misma institución Colaboradores (últimos 5 años), Investigadores de la misma institución Lista internacional: 1 o 2 de Asia, 1 o 2 de Europe, y 1 o 2 de las Américas Lista internacional: 1 o 2 de Asia, 1 o 2 de Europe, y 1 o 2 de las Américas Recomiende investigadores de nivel medio de diferentes países

La revisión por pares Seccion 6

La revisión por pares Puede ser una experiencia positiva y valiosa Evaluadores confirman la validez de la ciencia reportada. Expertos ofrecen su tiempo gratis para mejorar los manuscritos revisarlos y dar consejo sin costo Manuscritos deben evolucionar hasta ser: – Más impactantes – Sencillos de leer – Más útiles

Razones más comunes para el rechazo Carece de estructura adecuada Carece de los detalles necesarios para que los lectores comprendan plenamente el análisis de los autores No tiene nueva ciencia No explica claramente qué partes de los hallazgos son ciencia nueva, frente a lo que ya se conoce Carece de referencias Contiene teorías, conceptos o conclusiones que incompatibles con sus datos, argumentos e información No proporciona suficiente información sobre los materiales y métodos para permitir a otros científicos a repetir el experimento Carece descripciones claras o explicaciones de: Las hipótesis, el diseño experimental, características de la muestra y las estadísticas descriptivas Describe poco el diseño experimental, o el análisis estadístico defectuoso o insuficiente Tiene mala calidad lingüística

La revisión por pares Mejora su manuscrito Involúcrese en el proceso de arbitraje La revisión por pares es un proceso positivo que mejorará su manuscito La revisión por pares es un proceso positivo que mejorará su manuscito

La revisión por pares ¿Qué están buscando los revisores? La ciencia El manuscrito Hipótesis relevante Buen diseño experimental Metodología apropiada Buen análisis de datos Conclusiones válidas Hipótesis relevante Buen diseño experimental Metodología apropiada Buen análisis de datos Conclusiones válidas Flujo lógico de la información Estructura y formato del manuscrito Referencias apropiadas Alta legibilidad Flujo lógico de la información Estructura y formato del manuscrito Referencias apropiadas Alta legibilidad Resumen e introducción Métodos Resultados y cifras Discusión

La revisión por pares Carta de respuesta Responda claramente a cada comentario de sus revisores Responda claramente a cada comentario de sus revisores Fácil de ver los cambios Refiérase a los números de línea y página Utilice un color de fuente diferente Resalte el texto Revisión

La revisión por pares Escribiendo la carta de respuesta Marc Lippman, MD Editor-in-Chief Breast Cancer Research and Treatment 3 September 2013 Dear Dr Lippman, Re: Resubmission of manuscript reference No. WJS Please find attached a revised version of our manuscript originally entitled “Evaluation of the Glasgow prognostic score in patients undergoing curative resection for breast cancer liver metastases,” which we would like to resubmit for consideration for publication in the Breast Cancer Research and Treatment. The reviewer’s comments were highly insightful and enabled us to greatly improve the quality of our manuscript. In the following pages are our point-by-point responses to each of the comments. Revisions in the manuscript are shown as highlighted text. In accordance with the first comment, the title has been revised and the entire manuscript has undergone substantial English editing. We hope that the revisions in the manuscript and our accompanying responses will be sufficient to make our manuscript suitable for publication in the Breast Cancer Research and Treatment. Datos personalizados del editor Número ID del manuscrito Agradecimiento a los revisores Resaltar los cambios

La revisión por pares Estando de acuerdo con las revisiones Reviewer Comment: In your analysis of the data you have chosen to use a somewhat obscure fitting function (regression). In my opinion, a simple Gaussian function would have sufficed. Moreover, the results would be more instructive and easier to compare to previous results. Response: We agree with the reviewer’s assessment of the analysis. Our tailored function, in its current form, makes it difficult to tell that this measurement constitutes a significant improvement over previously reported values. We describe our new analysis using a Gaussian fitting function in our revised Results section (Page 6, Lines 12–18).

La revisión por pares Reviewer Comment: In your analysis of the data you have chosen to use a somewhat obscure fitting function (regression). In my opinion, a simple Gaussian function would have sufficed. Moreover, the results would be more instructive and easier to compare to previous results. Response: We agree with the reviewer’s assessment of the analysis. Our tailored function, in its current form, makes it difficult to tell that this measurement constitutes a significant improvement over previously reported values. We describe our new analysis using a Gaussian fitting function in our revised Results section (Page 6, Lines 12–18). Estando de acuerdo con los revisores Acuerdo

La revisión por pares Reviewer Comment: In your analysis of the data you have chosen to use a somewhat obscure fitting function (regression). In my opinion, a simple Gaussian function would have sufficed. Moreover, the results would be more instructive and easier to compare to previous results. Response: We agree with the reviewer’s assessment of the analysis. Our tailored function, in its current form, makes it difficult to tell that this measurement constitutes a significant improvement over previously reported values. We describe our new analysis using a Gaussian fitting function in our revised Results section (Page 6, Lines 12–18). Acuerdo Revisiones Estando de acuerdo con los revisores

La revisión por pares Reviewer Comment: In your analysis of the data you have chosen to use a somewhat obscure fitting function (regression). In my opinion, a simple Gaussian function would have sufficed. Moreover, the results would be more instructive and easier to compare to previous results. Response: We agree with the reviewer’s assessment of the analysis. Our tailored function, in its current form, makes it difficult to tell that this measurement constitutes a significant improvement over previously reported values. We describe our new analysis using a Gaussian fitting function in our revised Results section (Page 6, Lines 12–18). Acuerdo Revisiones Ubicación Estando de acuerdo con los revisores

La revisión por pares En desacuerdo con los revisores Reviewer Comment: In your analysis of the data you have chosen to use a somewhat obscure fitting function (regression). In my opinion, a simple Gaussian function would have sufficed. Moreover, the results would be more instructive and easier to compare to previous results. Response: Although a simple Gaussian fit would facilitate comparison with the results of other studies, our tailored function allows for the analysis of the data in terms of the Smith model [Smith et al., 1998]. We have now explained the use of this function and the Smith model in our revised Discussion section (Page 12, Lines 2–6). Si no está de acuerdo con los comentarios de la revisión, usted tiene que demostrar el por qué

La revisión por pares Reviewer Comment: In your analysis of the data you have chosen to use a somewhat obscure fitting function (regression). In my opinion, a simple Gaussian function would have sufficed. Moreover, the results would be more instructive and easier to compare to previous results. Response: Although a simple Gaussian fit would facilitate comparison with the results of other studies, our tailored function allows for the analysis of the data in terms of the Smith model [Smith et al., 1998]. We have now explained the use of this function and the Smith model in our revised Discussion section (Page 12, Lines 2–6). Evidencia En desacuerdo con los revisores

La revisión por pares Reviewer Comment: In your analysis of the data you have chosen to use a somewhat obscure fitting function (regression). In my opinion, a simple Gaussian function would have sufficed. Moreover, the results would be more instructive and easier to compare to previous results. Response: Although a simple Gaussian fit would facilitate comparison with the results of other studies, our tailored function allows for the analysis of the data in terms of the Smith model [Smith et al., 1998]. We have now explained the use of this function and the Smith model in our revised Discussion section (Page 12, Lines 2–6). Revisiones Evidencia En desacuerdo con los revisores

La revisión por pares Reviewer Comment: In your analysis of the data you have chosen to use a somewhat obscure fitting function (regression). In my opinion, a simple Gaussian function would have sufficed. Moreover, the results would be more instructive and easier to compare to previous results. Response: Although a simple Gaussian fit would facilitate comparison with the results of other studies, our tailored function allows for the analysis of the data in terms of the Smith model [Smith et al., 1998]. We have now explained the use of this function and the Smith model in our revised Discussion section (Page 12, Lines 2–6). Revisiones Ubicación Evidencia En desacuerdo con los revisores

La revisión por pares Reviewer comment: The authors looked for polymorphisms in the promoter region of the gene; however, they didn't evaluate the untranslated regions. That is one of my concerns about this methodology. Preguntas “Ocultas” ¿Es una pregunta? Si un comentario del revisor no está claro, pida ayuda de un colega

La revisión por pares Reviewer comment: The authors looked for polymorphisms in the promoter region of the gene; however, they didn't evaluate the untranslated regions. That is one of my concerns about this methodology. Preguntas “Ocultas” Rephrased question: Why didn’t the authors evaluate polymorphisms in the untranslated regions of the gene?

La revisión por pares Reviewer comment: The authors looked for polymorphisms in the promoter region of the gene; however, they didn't evaluate the untranslated regions. That is one of my concerns about this methodology. Response: In this study, we decided to focus on the promoter region of this gene because previous studies [Yajima et al., 2010; Jackson et al., 2011] have shown that its transcription was particularly affected. This has now been clarified in the Discussion section of our manuscript (Page 16, Line 24–28). Preguntas “Ocultas”

La revisión por pares Reviewer comment: The authors looked for polymorphisms in the promoter region of the gene; however, they didn't evaluate the untranslated regions. That is one of my concerns about this methodology. Response: In this study, we decided to focus on the promoter region of this gene because previous studies [Yajima et al., 2010; Jackson et al., 2011] have shown that its transcription was particularly affected. This has now been clarified in the Discussion section of our manuscript (Page 16, Line 24–28). Evidencia Preguntas “Ocultas”

La revisión por pares Reviewer comment: The authors looked for polymorphisms in the promoter region of the gene; however, they didn't evaluate the untranslated regions. That is one of my concerns about this methodology. Response: In this study, we decided to focus on the promoter region of this gene because previous studies [Yajima et al., 2010; Jackson et al., 2011] have shown that its transcription was particularly affected. This has now been clarified in the Discussion section of our manuscript (Page 16, Line 24–28). Revisiones Evidencia Preguntas “Ocultas”

La revisión por pares Reviewer comment: The authors looked for polymorphisms in the promoter region of the gene; however, they didn't evaluate the untranslated regions. That is one of my concerns about this methodology. Preguntas “Ocultas” Response: In this study, we decided to focus on the promoter region of this gene because previous studies [Yajima et al., 2010; Jackson et al., 2011] have shown that its transcription was particularly affected. This has now been clarified in the Discussion section of our manuscript (Page 16, Line 24–28). Revisiones Ubicación Evidencia

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