ETV+ DRV/r + RAL in Treatment-Experienced Patients TRIO Trial.

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Transcripción de la presentación:

ETV+ DRV/r + RAL in Treatment-Experienced Patients TRIO Trial

Etravirine + Darunavir/r + Raltegravir TRIO: Study Design Source: Yazdanpanah Y, et al. Clin Infect Dis. 2009;49: Trio Regimen Etravirine + Darunavir + Ritonavir + Raltegravir + OBT (n = 103) Study Design: TRIO Background: Phase 2, non-comparative trial assessing safety and efficacy of an antiretroviral regimen containing etravirine, darunavir boosted with ritonavir, and raltegravir in HIV-infected patients with multidrug-resistant virus Inclusion Criteria (n = 103) - Age ≥18 - On stable ARV regimen for ≥8 weeks - HIV RNA >1000 copies/ml - Mutations allowed: ≥3 PI, ≥3 NRTI, ≤ 3NNRTI - Naïve to etravirine, darunavir, and raltegravir Treatment Arms - Etravirine 200 mg bid + Darunavir 600 mg BID + Ritonavir 100mg bid + Raltegravir 400 mg bid + optimized background regimen (OBR) *OBT = NRTIs +/- Enfuvirtide

Etravirine + Darunavir/r + Raltegravir TRIO: Result Week 24 and 48: Virologic Response (Intention-to-treat Analysis) Source: Yazdanpanah Y, et al. Clin Infect Dis. 2009;49: /10389/103

Etravirine + Darunavir/r + Raltegravir TRIO: Result Week 24: Virologic Response (ITT Analysis), by Baseline HIV RNA Source: Yazdanpanah Y, et al. Clin Infect Dis. 2009;49: /10380/8813/15

Etravirine + Darunavir/r + Raltegravir TRIO: Conclusions Source: Yazdanpanah Y, et al. Clin Infect Dis. 2009;49: Conclusion: “In patients infected with multidrug-resistant virus who have few remaining treatment options, the combination of raltegravir, etravirine, and darunavir/ritonavir is well tolerated and is associated with a rate of virologic suppression similar to that expected in treatment-naive patients.”

Acknowledgment The National HIV Curriculum is an AIDS Education and Training Center (AETC) Program resource funded by the United States Health Resources and Services Administration. The project is led by the University of Washington and the AETC National Coordinating Resource Center. The content in this slide set does not represent the official views of the U.S. Department of Health and Human Services, Health Resources & Services Administration.