Prevalence of resistance-associated-mutations

Presentación del tema: "Prevalence of resistance-associated-mutations"— Transcripción de la presentación:

1 Prevalence of resistance-associated-mutations
in HIV-infected Mexican children after multiple ARV failure M.L. Cabrera Ruíz1, N. Pavia-Ruz2, L. Xochihua-Diaz1, P. Villalobos-Acosta2, R. Rodriguez-Diaz3, L. Fuentes-Romero3, R. Muñoz-Hernández4, L. Soto-Ramirez3 1Instituto Nacional de Pediatría, Clínica de VIH/SIDA, 2Hospital Infantil de México Federico Gómez, 3Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Unidad de Virología Molecular 4Universidad Nacional Autónoma de México, Clínicas de Atención a Niños con VIH, Mexico City, Mexico

2 Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure Objective To describe the most frequent RAMs in children failing to 2 or more ARV combinations from 3 tertiary care centers in Mexico City. Methods Of all genotypic resistance tests submitted to our referral laboratory from three pediatric AIDS clinics in Mexico City, we included 27 from children that have failed to at least 2 ARV combinations. We report here the prevalence of individual RAMs according to genotypic tests (Viroseq 2.0, Celera Diagnostics).

3 Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure Table 1. Characteristics and history of ARV treatment in the population studied Gender 14 male/ 13 female Age 9.8 (2-17) y ARV combinations 2 10 (37%) 3 6 (22.2%) >3 11 (40.7%) ARV treatment time 7.19 (1-12.8) y Thymidine analogs 6.87 (1-12.8) y 3TC/FTC 4.73 (0-10.1) y History of treatment NRTIs 27 (100%) NNRTIs 14 (52%) PIs 26 (96.3%) Actual treatment when resistance test performed 22 (81.5%) 4 (14.8%) Results 1

4 Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure 70 50 30 10 % NRTIs NNRTIs PIs Results 2

5 Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure Table 3. Compared frequency of main RAMs in HIV-infected Mexican children (C) and adults (A) after multiple ARV failure NRTIs NNRTIs PIs RAMs % C A 41L 70 21 103N 18 13 30N 11 4 67N 33 14 190A 8 46I 37 184V 77 181C 7 82A 210W 12 84V 215Y/F 63 28 90M 22 17 p= <0.001 p=0.6 p=0.109 Results 3