Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure M.L. Cabrera Ruíz 1, N. Pavia-Ruz 2, L. Xochihua-Diaz.

Presentación del tema: "Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure M.L. Cabrera Ruíz 1, N. Pavia-Ruz 2, L. Xochihua-Diaz."— Transcripción de la presentación:

1 Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure M.L. Cabrera Ruíz 1, N. Pavia-Ruz 2, L. Xochihua-Diaz 1, P. Villalobos-Acosta 2, R. Rodriguez-Diaz 3, L. Fuentes-Romero 3, R. Muñoz-Hernández 4, L. Soto-Ramirez 3 1Instituto Nacional de Pediatría, Clínica de VIH/SIDA, 2Hospital Infantil de México Federico Gómez, 3Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Unidad de Virología Molecular 4Universidad Nacional Autónoma de México, Clínicas de Atención a Niños con VIH, Mexico City, Mexico

2 Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure Objective To describe the most frequent RAMs in children failing to 2 or more ARV combinations from 3 tertiary care centers in Mexico City. Methods Of all genotypic resistance tests submitted to our referral laboratory from three pediatric AIDS clinics in Mexico City, we included 27 from children that have failed to at least 2 ARV combinations. We report here the prevalence of individual RAMs according to genotypic tests (Viroseq 2.0, Celera Diagnostics).

3 Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure Results 1 Table 1. Characteristics and history of ARV treatment in the population studied Gender14 male/ 13 female Age9.8 (2-17) y ARV combinations 210 (37%) 36 (22.2%) >311 (40.7%) ARV treatment time7.19 (1-12.8) y Thymidine analogs6.87 (1-12.8) y 3TC/FTC4.73 (0-10.1) y History of treatment NRTIs27 (100%) 3TC/FTC27 (100%) NNRTIs14 (52%) PIs26 (96.3%) Actual treatment when resistance test performed 3TC/FTC22 (81.5%) NNRTIs4 (14.8%)

4 Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure Results 2 NRTIsNNRTIsPIs 10 30 50 70 %

5 Prevalence of resistance-associated-mutations in HIV-infected Mexican children after multiple ARV failure Results 3 Table 3. Compared frequency of main RAMs in HIV-infected Mexican children (C) and adults (A) after multiple ARV failure NRTIsNNRTIsPIs RAMs% % % CACACA 41L7021103N181330N114 67N3314190A11846I3711 184V7713181C11782A337 210W331284V77 215Y/ F 632890M2217 p= <0.001 p=0.6p=0.109