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Thank You This PowerPoint document contains the images that you requested. Copyright Notice All Online Service materials, including, without limitation, text, pictures, graphics and other files and the selection and arrangement thereof are copyrighted materials of Ovid or its licensors, all rights reserved. Except for the Authorized Use specified above, you may not copy, modify or distribute any of the Online Service materials. You may not "mirror" any material contained on this Online Service on any other server. Any unauthorized use of any material contained on this Online Service may violate copyright laws, trademark laws, the laws of privacy and publicity and communications regulations and statutes.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 2 Table 1 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10): , September 3, Table 1. Frequency of EGFR Mutations.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 3 Figure 1 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10): , September 3, Figure 1. Enrollment and Outcomes.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 4 Table 2 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10): , September 3, Table 2. Characteristics and Treatment Responses of 217 Patients Receiving Erlotinib.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 5 Figure 2 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10): , September 3, Figure 2. Kaplan-Meier Curves of Progression-free and Overall Survival.Survival curves for 217 patients with EGFR mutations who received erlotinib therapy indicate the probability of progression-free survival (Panel A) and overall survival (Panel C) among all the patients and among those who received it as either first-line therapy or second-line therapy (Panels B and D). The cumulative number of events is listed for each time point.

Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 6 Table 3 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10): , September 3, Table 3. Multivariate Analyses of Progression-free and Overall Survival.