La salud y la enfermedad del hombre no solo están en relación con su organismo, sino también con el medio ambiente especialmente con los fenómenos atmosféricos Hipócrates Siglo V a.d.C.
Los grandes logros conseguidos frente a las enfermedades infecciosas y parasitarias, no han impedido que surjan brotes de enfermedades emergentes y reemergentes que se creían vencidas, causando problemas de salud animal y pública a nivel mundial
hematologic manifestations mechanisms 1. Bone marrow dysfunction a. Anemia or polycythemia b. Thrombocytopenia or thrombocytosis c. Leukopenia or leukocytosis 2. Hemolysis 3. Immune cytopenias 4. Alterations in hemostasis a. Acquired inhibitors to coagulation factors b. Acquired von Willebrand disease c. Acquired platelet dysfunction 5. Alterations in leukocyte function.
ANEMIA OF CHRONIC ILLNESS ● Normochromic, normocytic, occasionally microcytic ● Usually mild, characterized by decreased plasma iron. ● Impaired flow of iron from reticuloendothelial cells to the bone marrow ● Decreased sideroblasts in the bone marrow. Treatment involves treating the underlying illness. Iron is of little value because the iron is cleared by the reticuloendothelial system.
A - Anemia OF INFECTIONS ● Chronic infection is associated with the anemia of chronic illness. ● Acute infection, can produce transient bone marrow aplasia or selective transient erythrocytopenia. ● Bacterial illnesses may be associated with hemolysis.
8- Leptospirosis (Weil Disease) This disease is caused by Leptospira icterohaemorrhagiae. A coagulopathy occurs and can be corrected with vitamin K administration. Thrombocytopenia commonly occurs. DIC is rare.
Complications Renal failure Cardiac failure Respiratory failure Severe thrombocytopenia, hemoptysis Coagulopathy CNS involvement Pericarditis