UNIVERSIDAD DEL VALLE DE MÉXICO Matriz Extracelular DR. GERARDO CANCINO BALCÁZAR DIVISIÓN DE CIENCIAS DE LA SALUD
Matriz extracelular
Tejido Conectivo
Matriz extracelular
Cornea de rata
Glucosaminoglucanos
Hialurona
Proteoglicanos
Quimiocinas e inflamación
Proteoglicanos
Cartílago de rata
Proteoglicanos PROTEOGLYCANAPPROXIMATE MOLECULAR WEIGHT OF CORE PROTEIN TYPE OF GAG CHAINSNUMBER OF GAG CHAINS LOCATIONFUNCTIONS Aggrecan210,000chondroitin sulfate + keratan sulfate ~130cartilagemechanical support; forms large aggregates with hyaluronan Betaglycan36,000chondroitin sulfate/ dermatan sulfate 1cell surface and matrix binds TGF-β Decorin40,000chondroitin sulfate/ dermatan sulfate 1widespread in connective tissues binds to type I collagen fibrils and TGF-β Perlecan600,000heparan sulfate2–15basal laminaestructural and filtering function in basal lamina Syndecan-132,000chondroitin sulfate + heparan sulfate 1–3epithelial cell surfacecell adhesion; binds FGF and other growth factors Dally (in Drosophila)60,000heparan sulfate1–3cell surfaceco-receptor for Wingless and Decapentaplegic signaling proteins
Colagena
Migración de fibroblastos en colagena
Elastina
Aorta de perro
Elastina
Fibronectina
Actina Actina regula el ensamble de fibras de fibronectina
Lamina Basal
Cornea de embrión de pollo
ECM media la migración celular
Metaloproteasas