ENFERMEDAD DE ALZHEIMER ACTUALIDADES TERAPEUTICAS Dr. Rommel J Carrillo Várguez

DEMENCIA: El término... MARCO TULIO CICERON (106-43 a.C) Político, orador, escritor, romano En su ensayo,, “ De Senectute ” “... la pérdida de la memoria era consecuencia de una enfermedad ajena a la senectud...” Cicerón

ALOIS ALZHEIMER. El padre... En Noviembre de 1901, se presenta una mujer de 51 años al departamento de psiquiatría de la Universidad Johann Wolfang Goethe en Frankfurt. Cuadro Clínico: deterioro progresivo de memoria, afasia, alucinaciones auditivas, celotipia, paranoia, llanto frecuente e incompetencia psicosocial. AUGUSTE D

ALOIS ALZHEIMER. El padre... Alois Alzheimer, aborda y hace seguimiento por espacio de 2 años. realizando exploraciones clínicas y neuropsicológicas. 1903 Alzheimer se traslada a Munich. La paciente es seguida por médicos anónimos. 8 Abril 1906, fallece Auguste D. Se realiza necropsia cerebral. ALOIS ALZHEIMER Neurofibrillas

ALOIS ALZHEIMER. El padre... El 4 de Noviembre de 1906 durante “XXXVII Conferencia de Psiquiatras Alemanes” en Tubingen, se presenta el primer reporte anatomo-clínico de la futura enfermedad. “ Una enfermedad grave caracteristica de la corteza cerebral ” título de la publicación en 1907 Dibujo Original Microscopia Actual

ENFERMEDAD DE ALZHEIMER ALOIS ALZHEIMER. El padre... En la cuarta edición de su TRATADO DE PSIQUIATRIA KRAEPELIN, hace mención por primera vez de los casos de Auguste D y otros como la ENFERMEDAD DE ALZHEIMER

¿Y AHORA QUE?

Memory Introduction EU funding Constipation Introduction Aids Dementia Complex Introduction Self-help organisations Down's syndrome Research Introduction Disability Forum Introduction Agitation and nervousness Description Introduction Introduction 2001 General guidelines Provision of Care at home Introduction Aggressive behaviour Summary Introduction Palliative care Personal hygiene New on our site What is it? Interesting links Annual report Introduction Introduction Conferences on dementia Disclosure of the diagnosis Background information Our aims Clinging and following Country reports Care manual Onset of the disease   Join our mailing list Who is affected? Dressing Guidelines Communication Alcohol Related Dementia Lawnet Full document Mechanical restraint Anger Alzheimer projects Manual Suggest an event Psychotherapy Huntington's disease Involuntary placement Our opinion on...   EURODEM prevalence rates European developments Our opinion on...   Our full members Clinical trials Dealing with emotions Looking after yourself Dementia : definition 2000 Dental problems Neurological Associations Suggest a link Disorientation Eating and drinking Eyesight Statistics Alzheimer's disease   Is it hereditary? Binswanger's Disease Caring in the later stages Parkinson's disease Intranet Embarrassing behaviour Our associate members Anxiety and fear Memory and Communication   Recommendations   Relevant texts   Provision of care at home Incapable adults Our latest activities Social NGOs Our statutes Donations Care arrangements Tell us what you think! Genetic testing 1999 EP Resolutions Physical restraint Biomedical research Fits Working groups   1998 Can it be predicted? Creutzfeldt-Jacob Disease Ask Alzheimer Europe Sponsorship Other forms of dementia   Activities of our members Children's book Arranging residential care Relevant texts Care Manual Locking doors Daily life   Become full member Apathy Independent living Failure to recognise people Guidelines on restraint   Personal relationship Pharmaceutical Industry Our Board Diagnosis Lewy-Body Dementia Our staff Changes in mood   Conference proceedings Related disorders   Activities and exercise Financial statements Death and bereavement Hearing Younger people with dementia European projects   Become associate member Hiding/losing objects Human rights and Biomedicine Brusque changes of mood Children's book Research Advance directives Tagging Multi-Infarct Dementia Annual reports   ERICA Safety Repetitive questioning Changes in behaviour   Incontinence Having depression AE Networking   Video surveillance Other news Brain tissue donations Treatment Legal rights of patients Telephone Helpline   Medical and physical issues   Passive alarms Living alone Frustration Pick's Disease Main characteristics Sexually behaviour Jerking movements Hallucinations Moving the person with dementia Helping children to cope Coping with caring   Three stages Sleeplessness Medication as restraint Rural areas Loss of manual skills Current research Over-reaction Early onset dementia Wandering Psychological restraint YOUR COMMENTS... Pressure sores De acuerdo las tendencias actuales de prevalencia de (30-50%) en mayores de 85 años: EPIDEMIA

ALZHEIMER D. DE PICK CREUTZFEL-JACKOB PRIMARIA DEMENCIA PARKINSON VASCULAR HUNTINGTON Alcohólica SECUNDARIA DETERIORO COGNOSCITIVO: DEPRESION DELIRIUM DISTIROIDISMO PSICOFÁRMACOS DEFICIT NUTRICIONAL PSEUDO DEMENCIA

Criterios Diagnósticos SIGLO XX. Criterios Diagnósticos Estudios Epidemiológicos Prevalencia a nivel mundial

FISIOPATOLOGIA:

Inhibidores de Colinesterasa INHIBIDORES NMDA memantina –AKATINOL- Farmacológico Inhibidores de Colinesterasa INHIBIDORES NMDA memantina –AKATINOL- Vitaminas, oxigenadores cerebrales, transfusiones de células de embriones NO SIRVEN

SOBRE ESTIMULACION MEMANTINA (AKATINOL) DAÑO NEURONAL

1999 fase clínica 20 pacientes Personal hygiene Memory Palliative care Introduction Introduction Research Provision of Care at home Agitation and nervousness Description Disclosure of the diagnosis Introduction Disability Forum General guidelines Summary Introduction Introduction 2001 Aids Dementia Complex EU funding Introduction Aggressive behaviour Introduction Down's syndrome Introduction Introduction Introduction Self-help organisations Annual report Background information What is it? Interesting links New on our site Constipation Conferences on dementia Introduction EURODEM prevalence rates Alcohol Related Dementia Who is affected? Mechanical restraint Dementia : definition Our aims Full document Dealing with emotions Anger Country reports Lawnet Our full members Dental problems Dressing Looking after yourself Clinging and following Huntington's disease Communication Manual Onset of the disease   Suggest a link Our opinion on...   Guidelines Care manual Clinical trials Our opinion on...   2000 Suggest an event Psychotherapy European developments Join our mailing list Neurological Associations Involuntary placement Alzheimer projects Parkinson's disease Disorientation Incapable adults Provision of care at home Eating and drinking Eyesight Our latest activities Embarrassing behaviour Our associate members 1999 Intranet Anxiety and fear Recommendations   Relevant texts   Care arrangements Tell us what you think! Our statutes Caring in the later stages Genetic testing Is it hereditary? Binswanger's Disease Social NGOs Physical restraint Alzheimer's disease   Memory and Communication   EP Resolutions Donations Statistics Become full member Sponsorship Creutzfeldt-Jacob Disease Arranging residential care Can it be predicted? 1998 Ask Alzheimer Europe Children's book Fits Other forms of dementia   Care Manual Independent living Locking doors Working groups   Personal relationship Daily life   Biomedical research Apathy Failure to recognise people Guidelines on restraint   Activities of our members Relevant texts Pharmaceutical Industry Our Board European projects   Changes in mood   Tagging Advance directives Diagnosis Our staff Related disorders   Younger people with dementia Children's book Hearing Brusque changes of mood Research Hiding/losing objects Financial statements Conference proceedings Human rights and Biomedicine Activities and exercise Death and bereavement Lewy-Body Dementia Become associate member Multi-Infarct Dementia Annual reports   ERICA Safety Video surveillance Repetitive questioning Changes in behaviour   Having depression AE Networking   Incontinence Legal rights of patients Treatment Brain tissue donations Other news Medical and physical issues   Frustration Living alone Telephone Helpline   Main characteristics Sexually behaviour Jerking movements Pick's Disease Passive alarms Medication as restraint Rural areas Coping with caring   Helping children to cope Moving the person with dementia Three stages Hallucinations Sleeplessness Over-reaction Loss of manual skills Wandering Current research Psychological restraint Early onset dementia Pressure sores YOUR COMMENTS... Otras Opciones Farmacológicas Combinación de aminoácidos de proteína Beta amiloide con otros prótidos (AN 1792) en 1997. 1999 fase clínica 20 pacientes 2002 Fase clínica II suspensión del protocolo por presencia de meningitis aséptica en 15 pacientes ussuarios Dublin, Irlanda THE LANCET Neurology Vol 1 May 2002

1- hay opciones farmacológicas reales CONCLUSIONES 1- hay opciones farmacológicas reales 2- RESULTADOS MODESTOS PERO NOTABLES 3- MEJORAN SINTOMATICAMENTE, CONDUCTUALMENTE Y ¿DETIENEN EVOLUCION? 4- LOS PACIENTES DEBEN RECIBIR ESTOS FARMACOS