DSS/HS + vildagliptin-low dose DSS/HS + vildagliptin-high dose Supplemental Figure S1 DSS/HS + vildagliptin-low dose DSS/HS + vildagliptin-high dose DSS/NS + vehicle DSS/HS + vehicle A B C 140 140 14 135 SBP (mmHg) 135 ∆SBP (dark-light period) (mmHg) 12 SBP (mmHg) 130 130 10 125 125 120 120 8 115 115 6 110 110 105 105 4 100 100 2 95 Dark period Light period 95 90 90 10:PM 11:PM 12:AM 1:AM 2:AM 3:AM 10:AM 11:AM 12:PM 1:PM 2:PM 3:PM Dark period Light period Time (O`clock)
DSS/HS + vildagliptin-low dose DSS/HS + vildagliptin-high dose Supplemental Figure S2 DSS/HS + vildagliptin-low dose DSS/HS + vildagliptin-high dose DSS/NS + vehicle DSS/HS + vehicle A B C 140 140 *** 14 *** ∆SBP (dark-light period) (mmHg) SBP (mmHg) 135 SBP (mmHg) 135 ‡ 12 130 130 ‡ †† § *** ‡ 125 125 10 120 120 † †† † 8 115 115 6 110 110 105 105 4 100 100 2 95 Dark period Light period 95 90 90 10:PM 11:PM 12:AM 1:AM 2:AM 3:AM 10:AM 11:AM 12:PM 1:PM 2:PM 3:PM Dark period Light period
DSS/HS + vildagliptin-low dose DSS/HS + vildagliptin-high dose Supplemental Figure S3 DSS/HS + vildagliptin-low dose DSS/HS + vildagliptin-high dose DSS/NS + vehicle DSS/HS + vehicle SBP (mmHg) 140 SBP (mmHg) 140 14 135 ∆SBP (dark-light period) (mmHg) 135 12 130 130 125 125 10 120 120 * ‡ 8 115 115 †† 110 110 6 † 105 105 4 100 100 2 95 95 Dark period Light period 90 90 10:PM 11:PM 12:AM 1:AM 2:AM 3:AM 10:AM 11:AM 12:PM 1:PM 2:PM 3:PM Dark period Light period