High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous.

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Transcripción de la presentación:

High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma by Bruno Paiva, Norma C. Gutiérrez, Laura Rosiñol, María-Belén Vídriales, María-Ángeles Montalbán, Joaquín Martínez-López, María-Victoria Mateos, María-Teresa Cibeira, Lourdes Cordón, Albert Oriol, María-José Terol, María-Asunción Echeveste, Raquel de Paz, Felipe de Arriba, Luis Palomera, Javier de la Rubia, Joaquín Díaz-Mediavilla, Anna Sureda, Ana Gorosquieta, Adrian Alegre, Alejandro Martin, Miguel T. Hernández, Juan-José Lahuerta, Joan Bladé, and Jesús F. San Miguel Blood Volume 119(3):687-691 January 19, 2012 ©2012 by American Society of Hematology

Outcome of patients in CR at day +100 after HDT/ASCT included in the GEM2000 and GEM2005 < 65y trials. Outcome of patients in CR at day +100 after HDT/ASCT included in the GEM2000 and GEM2005 < 65y trials. (A-B) TTP and OS for patients in CR versus those in less than CR at day +100 after HDT/ASCT. Broken lines in panel B indicate TTP and OS for patients who lost their CR status during the first year after HDT/ASCT (unsustained CR; n = 29 [12%]). (C-D), Landmark analysis for TTP and OS after day +100 after HDT/ASCT of patients (n = 110) in CR according to the pattern of FISH cytogenetics at baseline and immunophenotypic CR status at day +100 after HDT/ASCT. Bruno Paiva et al. Blood 2012;119:687-691 ©2012 by American Society of Hematology