Genetic ancestry component proportions are correlated with HIV disease progression Daniela Garrido-Rodríguez, Santiago Ávila-Ríos, Humberto Valenzuela-Ponce,

Presentación del tema: "Genetic ancestry component proportions are correlated with HIV disease progression Daniela Garrido-Rodríguez, Santiago Ávila-Ríos, Humberto Valenzuela-Ponce,"— Transcripción de la presentación:

1 Genetic ancestry component proportions are correlated with HIV disease progression Daniela Garrido-Rodríguez, Santiago Ávila-Ríos, Humberto Valenzuela-Ponce, Thalía A. García-Téllez, Veronica Quiroz-Morales, Claudia García-Morales, Maribel Soto-Nava, Akio Murakami-Ogasawara, Juan Carlos Fernandez-Lopez, Gustavo Reyes-Terán

2 Several genetic factors are associated to HIV disease outcome HLA KIR Peptide KIR3DL1/S1 in combination with HLA-Bw4 80Ille Slow progression to AIDS Slow CD4+ T cell decline KIR2DL2/S2 in combination with HLA-C1 80Asn Fast decrease of CD4+ T cell counts Caucasian populations

3 Mexican mestizos are an admixed popultion with Amerindian, European and African genetic ancestry components -Genetic ancestry of 476 individuals was succesfully performed using a previously described panel of 128 AIMs -0.594 AMI -0.38 EUR -0.026 AFR

4 Significant effect of AMI and EUR genetic ancestry proportions on CD4+ T cell counts

5 In general, significant KIR and HLA protective effects were stronger for individuals with higher EUR ancestry Putative novel KIR-HLA associations with CD4+ T cell counts were observed only when stratifying genetic ancestry components

6 Conclusions Genetic stratification within a population is important when assessing the effect of genetic factors on HIV disease outcome. Differential effects of specific genetic factors observed in individuals with distinct genetic ancestry components in admixed populations. HLA and KIR effects can partially explain differences observed in pVL setpoint and CD4+ T cell counts in individuals with different genetic ancestry components. The possible effect of other genetic factors as well as socio- demographic factors needs to be further assessed.

7 ACKNOWLEDGEMENTS Dr. Gustavo Reyes Ter á n Dr. Santiago Ávila Ríos CIENI, INER Blood donors Blood donors UCSF, San Francisco, USA Douglas Nixon Thalía García Daniela Garrido Verónica Quiroz Humberto Valenzuela HLA typing Collaborators Maribel Soto Nava Tania Escamilla Margarita Matías Claudia García Daniela Tapia Ana Paola Carranco Juan Blanco CIENI students Ramón Hern á ndez Edna Rodríguez Silvia del Arenal Mario Preciado Carolina Demeneghi Raymundo Gonz á lez Israel Molina Clinical Lab Zeidy Arenas Sandra Zamora Carolina Pérez Eduardo López Berenice Cancino Administrative staff Israel Maldonada Esteb á n Paz Pablo César Informatics staff Center for Cancer Research, Frederick MD, USA Carrington, Mary Martin, Maureen Qi, Ying