4 Typical prokaryotic (left) and eukaryotic (right) cells. W. Ford Doolittle Nature 392, 15-16, 1998
5 The endosymbiont hypothesis for the origin of mitochondria (1970) W. Ford Doolittle Nature 392, 15-16, 1998
6 Endosymbiosis theory (Lynn Margulis, 1970’s) Model for origin of eukaryotes(A) endomembrane system of eukaryotes may have evolved from specialized infoldings of plasma membrane of ancestral prokaryotes(B) chloroplasts are descendants of photosynthetic prokaryotes, probably cyanobacteria- proposed ancestors of mitochondria were endosymbiotic bacteria that were aerobic heterotrophsa. may have first gained entry into larger cells as undigested prey or internal parasitesBe a good skeptic! Where’s the evidence?
11 Mitochondrial volume homeostasis mediated by K+ transport and the PTP Mitochondrial volume homeostasis mediated by K+ transport and the PTP. The scheme summarizes the role of K+ fluxes and PTP opening in mitochondrial volume homeostasis. Kc, potassium channels; ETC, electron transfer chain; Mkh1, essential mitochondrial KHE factor; Δψ, mitochondrial membrane potential difference; PTP, permeability transition pore