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Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy.

Publicada porValentín Montero Cortés Modificado hace 5 años

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Presentación del tema: "Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy."— Transcripción de la presentación:

1 Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy Brain Initiative (FACEHBI) study baseline results  Sonia Moreno–Grau, Octavio Rodríguez-Gómez, Ángela Sanabria, Alba Pérez-Cordón, Domingo Sánchez-Ruiz, Carla Abdelnour, Sergi Valero, Isabel Hernández, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Silvia Gil, Miguel Ángel Santos- Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Marina Guitart, Anna Gailhajanet, Itziar de Rojas, Óscar Sotolongo-Grau, Susana Ruiz, Nuria Aguilera, Judith Papasey, Elvira Martín, Esther Peleja, Francisco Lomeña, Francisco Campos, Assumpta Vivas, Marta Gómez-Chiari, Miguel Ángel Tejero, Joan Giménez, Manuel Serrano-Ríos, Adelina Orellana, Lluís Tárraga, Agustín Ruiz, Mercè Boada C. Abdelnour, N. Aguilera, M. Alegret, M. Berthier, M. Boada, M. Buendia, S. Bullich, F. Campos, P. Cañabate, C. Cuevas, I. de Rojas, A. Espinosa, A. Gailhajenet, S. Diego, S. Gil, J. Giménez, R. Gismondi, M. Gómez-Chiari, M. Guitart, B. Hernández-Olasagarre, I. Hernández, M. Ibarria, A. Lafuente, F. Lomeña, E. Martín, J. Martínez, A. Mauleón, G. Monté, M. Moreno, S. Moreno-Grau, L. Núñez, A. Orellana, G. Ortega, A. Páez, A. Pancho, J. Pavía, E. Pelejà, A. Pérez-Cordon, V. Pérez-Grijalba, P. Pesini, S. Preckler, O. Rodríguez- Gómez, J. Romero, M. Rosende-Roca, A. Ruiz, S. Ruiz, A. Sanabria, D. Sánchez-Ruiz, M.A. Santos-Santos, M. Sarasa, O. Sotolongo- Grau, L. Tárraga, M.A. Tejero, M. Torres, S. Valero, L. Vargas, A. Vivas Sonia Moreno–Grau, Octavio Rodríguez-Gómez, Ángela Sanabria, Alba Pérez-Cordón, Domingo Sánchez-Ruiz, Carla Abdelnour, Sergi Valero, Isabel Hernández, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Silvia Gil, Miguel Ángel Santos-Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Marina Guitart, Anna Gailhajanet, Itziar de Rojas, Óscar Sotolongo-Grau, Susana Ruiz, Nuria Aguilera, Judith Papasey, Elvira Martín, Esther Peleja, Francisco Lomeña, Francisco Campos, Assumpta Vivas, Marta Gómez-Chiari, Miguel Ángel Tejero, Joan Giménez, Manuel Serrano-Ríos, Adelina Orellana, Lluís Tárraga, Agustín Ruiz, Mercè Boada C. Abdelnour, N. Aguilera, M. Alegret, M. Berthier, M. Boada, M. Buendia, S. Bullich, F. Campos, P. Cañabate, C. Cuevas, I. de Rojas, A. Espinosa, A. Gailhajenet, S. Diego, S. Gil, J. Giménez, R. Gismondi, M. Gómez-Chiari, M. Guitart, B. Hernández-Olasagarre, I. Hernández, M. Ibarria, A. Lafuente, F. Lomeña, E. Martín, J. Martínez, A. Mauleón, G. Monté, M. Moreno, S. Moreno-Grau, L. Núñez, A. Orellana, G. Ortega, A. Páez, A. Pancho, J. Pavía, E. Pelejà, A. Pérez-Cordon, V. Pérez-Grijalba, P. Pesini, S. Preckler, O. Rodríguez-Gómez, J. Romero, M. Rosende-Roca, A. Ruiz, S. Ruiz, A. Sanabria, D. Sánchez-Ruiz, M.A. Santos-Santos, M. Sarasa, O. Sotolongo-Grau, L. Tárraga, M.A. Tejero, M. Torres, S. Valero, L. Vargas, A. Vivas  Alzheimer's & Dementia: The Journal of the Alzheimer's Association  Volume 14, Issue 5, Pages (May 2018) DOI: /j.jalz Copyright © 2017 The Authors Terms and Conditions

2 Fig. 1 Forest plot for the effect of APOE ε4 genotype in risk to be diagnosed with SCD. Abbreviations: ADNI, Alzheimer's Disease Neuroimaging Initiative; APOE, apolipoprotein E; CI, confidence interval; OR, odds ratio; SCD, subjective cognitive decline. For further information about Czech brain aging study, LASA, Vallecas Study, and PATH Study, see references [45], [46], [47] and [48], respectively. Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , DOI: ( /j.jalz ) Copyright © 2017 The Authors Terms and Conditions

3 Fig. 2 Effect of APOE allele dosage in cerebral amyloid burden for the FACEHBI cohort. Mean is represented in white. Abbreviations: APOE, apolipoprotein E; SUVR, standardized uptake value ratio. Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , DOI: ( /j.jalz ) Copyright © 2017 The Authors Terms and Conditions

4 Fig. 3 Forest plot for (A) the effect of APOE ε4 and (B) the age, in amyloid burden across clinical categories. Abbreviations: AD, Alzheimer's disease; ADNI, Alzheimer's Disease Neuroimaging Initiative; APOE, apolipoprotein; EMCI, early mild cognitive impairment; FACEHBI, Fundacio ACE Healthy Brain Initiative; HC, healthy control; LMCI, late mild cognitive impairment; PET, positron emission tomography; SCD, subjective cognitive decline; SMC, subjective memory impairment. Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , DOI: ( /j.jalz ) Copyright © 2017 The Authors Terms and Conditions

5 Supplementary Fig. 4 Correlation between APOE allele dosage and brain amyloid burden per clinical category. Abbreviations: AD, Alzheimer's disease; ADNI, Alzheimer's Disease Neuroimaging Initiative; APOE, apolipoprotein; EMCI, early mild cognitive impairment; FACEHBI, Fundacio ACE Healthy Brain Initiative; HC, healthy control; LMCI, late mild cognitive impairment; SCD, subjective cognitive decline. Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , DOI: ( /j.jalz ) Copyright © 2017 The Authors Terms and Conditions

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