UNIVERSIDAD DEL VALLE DE MÉXICO RECEPTORES CELULARES DR. GERARDO CANCINO BALCÁZAR DIVISIÓN DE CIENCIAS DE LA SALUD.

Presentación del tema: "UNIVERSIDAD DEL VALLE DE MÉXICO RECEPTORES CELULARES DR. GERARDO CANCINO BALCÁZAR DIVISIÓN DE CIENCIAS DE LA SALUD."— Transcripción de la presentación:

1 UNIVERSIDAD DEL VALLE DE MÉXICO RECEPTORES CELULARES DR. GERARDO CANCINO BALCÁZAR DIVISIÓN DE CIENCIAS DE LA SALUD

2 Comunicación Celular

3 Receptores celulares

4 Comunicación Celular

5 Receptores unidos a proteínas G

6 Receptores tipo canal ionico

7 Receptores tipo tirosin cinasas

8 Receptores con actividad intrinsica

9 Segundos Mensajeros

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11 AMPc

12 TissueHormone Inducing Rise in cAMPMetabolic Response AdiposeEpinephrine; ACTH; glucagonIncrease in hydrolysis of triglyceride; decrease in amino acid uptake LiverEpinephrine; norepinephrine; glucagonIncrease in conversion of glycogen to glucose; inhibition of synthesis of glycogen; increase in amino acid uptake; increase in gluconeogenesis (synthesis of glucose from amino acids) Ovarian follicle FSH; LHIncrease in synthesis of estrogen, progesterone Adrenal cortex ACTHIncrease in synthesis of aldosterone, cortisol Cardiac muscle cells EpinephrineIncrease in contraction rate ThyroidTSHSecretion of thyroxine Bone cellsParathyroid hormoneIncrease in resorption of calcium from bone Skeletal muscle EpinephrineConversion of glycogen to glucose IntestineEpinephrineFluid secretion KidneyVasopressinResorption of water Blood platelets Prostaglandin IInhibition of aggregation and secretion

13 Segundos Mensajeros

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15 TissueHormone Inducinga Rise in IP 3 Cellular Response Pancreas (acinar cells)AcetylcholineSecretion of digestive enzymes, such as amylase and trypsinogen Parotid (salivary gland)AcetylcholineSecretion of amylase Pancreas (β cells of islets)AcetylcholineSecretion of insulin Vascular or stomach smooth muscleAcetylcholineContraction LiverVasopressinConversion of glycogen to glucose Blood plateletsThrombinAggregation, shape change, secretion of hormones Mast cellsAntigenHistamine secretion FibroblastsPeptide growth factors, such as bombesin and PDGF DNA synthesis, cell division Sea urchin eggsSpermatozoaRise of fertilization membrane

16 Calcio

17 Proteínas de señalización

18 Proteínas cambiadoras de GTPasas

19 Proteínas cinasas

20 Proteínas adaptadoras

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22 Receptores Intracelulares

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