Cyclosporine Use in Epidermal Necrolysis Is Associated with an Important Mortality Reduction: Evidence from Three Different Approaches Carlos González-Herrada,

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Transcripción de la presentación:

Cyclosporine Use in Epidermal Necrolysis Is Associated with an Important Mortality Reduction: Evidence from Three Different Approaches Carlos González-Herrada, Sara Rodríguez-Martín, Lucía Cachafeiro, Victoria Lerma, Olga González, José A. Lorente, Antonio Rodríguez-Miguel, Jessica González-Ramos, Gaston Roustan, Elena Ramírez, Teresa Bellón, Francisco J. de Abajo Teresa Bellón, Rosario Cabañas, Lucía Cachafeiro, Abelardo García de Lorenzo, Jessica González-Ramos, Olga Hernández, Pedro Herranz, Elena Ramírez, Elena Ruíz Bravo, Yolanda Alonso, Jose Antonio Aramburu, Natalia Cámara, Olga González, Carlos González-Herrada, Olga Laosa, José A. Lorente, Amelia Moscoso, Concepción Payares, Gastón Roustan, Francisco J. de Abajo, Alicia Quesada, Victoria Lerma, Sara Rodríguez-Martín Carlos González-Herrada, Sara Rodríguez-Martín, Lucía Cachafeiro, Victoria Lerma, Olga González, José A. Lorente, Antonio Rodríguez-Miguel, Jessica González-Ramos, Gaston Roustan, Elena Ramírez, Teresa Bellón, Francisco J. de Abajo Teresa Bellón, Rosario Cabañas, Lucía Cachafeiro, Abelardo García de Lorenzo, Jessica González-Ramos, Olga Hernández, Pedro Herranz, Elena Ramírez, Elena Ruíz Bravo, Yolanda Alonso, Jose Antonio Aramburu, Natalia Cámara, Olga González, Carlos González- Herrada, Olga Laosa, José A. Lorente, Amelia Moscoso, Concepción Payares, Gastón Roustan, Francisco J. de Abajo, Alicia Quesada, Victoria Lerma, Sara Rodríguez-Martín Journal of Investigative Dermatology Volume 137, Issue 10, Pages 2092-2100 (October 2017) DOI: 10.1016/j.jid.2017.05.022 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Flow chart of epidermal necrolysis patients included in the study by hospital and treatment. A total of 71 patients with a validated diagnosis of epidermal necrolysis were admitted to either of the participating burn units, University Hospital of Getafe (UHG) and La Paz University Hospital (LPUH). Patients from the region of Madrid (n = 42) were selected to take part in the “natural experiment”. All 71 patients were included in the observed versus expected analysis. CsA, cyclosporine; IVIg, intravenous immunoglobulin. Journal of Investigative Dermatology 2017 137, 2092-2100DOI: (10.1016/j.jid.2017.05.022) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Forest plot of the meta-analysis. The observed and expected deaths reported by each study among patients treated with cyclosporine and the MRR (dark square) with 95% confidence interval (horizontal line) are shown. Studies are identified by first author and year of publication. In studies with zero observed deaths, a continuity correction factor of 1 was added to both the observed and the expected deaths (data not shown).The pooled results are shown in two strata: (i) the five studies found in the literature and (ii) all studies, including ours. The continuous vertical line represents the null value of the MRR; values located on the left are compatible with a mortality risk reduction and those located on the right with an increased risk. CI, confidence interval; MRR, mortality risk ratio. Journal of Investigative Dermatology 2017 137, 2092-2100DOI: (10.1016/j.jid.2017.05.022) Copyright © 2017 The Authors Terms and Conditions