Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy.

Slides:

Advertisements

Presentaciones similares

HLA-DRB1*15:01 allele protects from asthma susceptibility María Pino-Yanes, PhD, Almudena Corrales, CLT, Marialbert Acosta-Herrera, MSc, Eva Pérez-Rodríguez,

Advertisements

Cervical pessary to prevent preterm birth in women with twin gestation and sonographic short cervix: a multicenter randomized controlled trial (PECEP-Twins)

The therapeutic role of fulvestrant in the management of patients with hormone receptor-positive breast cancer Eva Ciruelos, Tomás Pascual, María Luisa.

Study design for the “effect of METOprolol in CARDioproteCtioN during an acute myocardial InfarCtion” (METOCARD-CNIC): A randomized, controlled parallel-group,

Novel Genomic Imbalances in B-Cell Splenic Marginal Zone Lymphomas Revealed by Comparative Genomic Hybridization and Cytogenetics Jesús María Hernández,

Crohn's disease and cheilitis granulomatosa: Role of silicone fillers Helena Álvarez-Garrido, MD, Laura Pericet-Fernández, MD, Gerardo Martínez-García,

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the.

Volume 128, Issue 3, Pages (March 2005)

Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy.

Defining the Asthma-COPD Overlap Syndrome in a COPD Cohort

Volume 22, Issue 3, Pages (June 2003)

Incidence, Risk Factors, and Outcome of Cytomegalovirus Infection and Disease in Patients Receiving Prophylaxis with Oral Valganciclovir or Intravenous.

Cognitive Function in Patients With Prostate Cancer Receiving Luteinizing Hormone- Releasing Hormone Analogues: A Prospective, Observational, Multicenter.

Volume 68, Issue 2, Pages (August 2015)

HLA-DRB1*15:01 allele protects from asthma susceptibility

Defining the Asthma-COPD Overlap Syndrome in a COPD Cohort

Estimating Preferences for Treatments in Patients With Localized Prostate Cancer Mónica Ávila, MPH, Virginia Becerra, MPH, Ferran Guedea, MD, PhD, José.

Volume 11, Issue 3, Pages (January 2009)

Anaesthetic and cardiorespiratory effects of a constant rate infusion of fentanyl in isoflurane-anaesthetized sheep Francisco J Funes, María del Mar.

Week 4 response predicts sustained virological response to all-oral direct-acting antiviral-based therapy in cirrhotic patients with hepatitis C virus.

Volume 58, Issue 6, Pages (June 2013)

Volume 129, Issue 2, Pages (August 2005)

Oral Beclomethasone Dipropionate for the Treatment of Gastrointestinal Chronic Graft- versus-Host Disease Fernanda N. Villanueva, Jose Antonio Pérez-Simón,

Predictors of early mortality in very elderly patients with bacteremia: a prospective multicenter cohort Pilar Retamar, María Dolores López-Prieto, Fernando.

A Scoring System to Determine Risk of Delayed Bleeding After Endoscopic Mucosal Resection of Large Colorectal Lesions Eduardo Albéniz, María Fraile,

Empirical and targeted therapy of candidemia with fluconazole versus echinocandins: a propensity score–derived analysis of a population-based, multicentre.

Safety and effectiveness of immunotherapy in patients with indolent systemic mastocytosis presenting with Hymenoptera venom anaphylaxis David González.

Volume 15, Issue 7, Pages (July 2014)

Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome Juan Sanchis, MD, Clara Bonanad, MD, Vicente.

Association of Adiponectin with Subclinical Atherosclerosis in a Mexican-Mestizo Population Juan Gabriel Juárez-Rojas, Rosalinda Posadas-Sánchez, María.

Volume 104, Issue 12, Pages (December 2010)

High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium.

Volume 68, Issue 2, Pages (August 2015)

Oral Beclomethasone Dipropionate for the Treatment of Gastrointestinal Chronic Graft- versus-Host Disease Fernanda N. Villanueva, Jose Antonio Pérez-Simón,

Enterococcal endocarditis in a patient with a renal oncocytoma

Safety and effectiveness of immunotherapy in patients with indolent systemic mastocytosis presenting with Hymenoptera venom anaphylaxis David González.

Efficacy and Safety of Out-of-Hospital Intravenous Metoprolol Administration in Anterior ST-Segment Elevation Acute Myocardial Infarction: Insights From.

Volume 9, Issue 4, Pages (April 2017)

Updated Frequency of EGFR and KRAS Mutations in NonSmall-Cell Lung Cancer in Latin America: The Latin-American Consortium for the Investigation of Lung.

Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion Begoña Pineda, B.S., Carlos.

Volume 121, Issue 2, Pages (August 2001)

Impact of fluconazole susceptibility on the outcome of patients with candidaemia: data from a population-based surveillance M. Fernández-Ruiz, J. Guinea,

Aortic Valve-Sparing in 37 Patients With Marfan Syndrome: Midterm Results With David Operation Alberto Forteza, MD, Javier De Diego, MD, Jorge Centeno,

Natural evolution of skin test sensitivity in patients allergic to β-lactam antibiotics Miguel Blanca, MD, PhDa, Maria Jose Torres, MD, PhDa, Juan Jesus.

Cyclosporine Use in Epidermal Necrolysis Is Associated with an Important Mortality Reduction: Evidence from Three Different Approaches Carlos González-Herrada,

Cutaneous lymphoma in a patient with ulcerative colitis after immunosuppressive therapy Maria Rojas-Feria, Mohammed Eslam, Manuel Castro-Fernández, Pedro.

Week 4 response predicts sustained virological response to all-oral direct-acting antiviral-based therapy in cirrhotic patients with hepatitis C virus.

Volume 128, Issue 3, Pages (March 2005)

Evaluation of the possible influence of trailing and paradoxical effects on the clinical outcome of patients with candidemia C. Rueda, M. Puig-Asensio,

Volume 121, Issue 4, Pages (October 2001)

Causal Model of Survival After Pulmonary Metastasectomy of Colorectal Cancer: A Nationwide Prospective Registry Raul Embun, MD, Juan J. Rivas de Andrés,

Severe Infections after Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation in Adults: Comparison of Cord Blood Transplantation with Peripheral.

Effects of Burst-Type Transcutaneous Electrical Nerve Stimulation on Cervical Range of Motion and Latent Myofascial Trigger Point Pain Sensitivity Ángel.

Incidence, Risk Factors, and Outcome of Cytomegalovirus Infection and Disease in Patients Receiving Prophylaxis with Oral Valganciclovir or Intravenous.

Osteoarthritis and Cartilage

Typhoid fever outbreak with severe complications in Yucatan, Mexico

The Annals of Thoracic Surgery

Development of a Six-Month Prognostic Index in Patients With Advanced Chronic Medical Conditions: The PALIAR Score Máximo Bernabeu-Wittel, PhD, José.

Bronchopulmonary infection–colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study Juan de Dios Caballero,

Methylation Analysis of MLH1 Improves the Selection of Patients for Genetic Testing in Lynch Syndrome Lucía Pérez-Carbonell, Cristina Alenda, Artemio.

Zygophyllum fabago L: A new source of allergenic pollen

An Assessment of the Effect of Human Herpesvirus-6 Replication on Active Cytomegalovirus Infection after Allogeneic Stem Cell Transplantation Nuria Tormo,

Volume 70, Issue 5, Pages (May 2019)

Acute Type A Aortic Dissection After Sternal Bone Marrow Puncture

Annual Incidence of Hepatocellular Carcinoma Among Patients With Alcoholic Cirrhosis and Identification of Risk Groups Alejo Mancebo, M. Luisa González–Diéguez,

Alberto Ruano-Ravina, PharmD, MPH, PhD, Marco F

Risk-factors for the acquisition of imipenem-resistant Acinetobacter baumannii in Spain: a nationwide study J.M. Cisneros, J. Rodríguez-Baño, F. Fernández-Cuenca,

Biofilm production is not associated with poor clinical outcome in 485 patients with Staphylococcus aureus bacteraemia M. Guembe, B. Alonso, J. Lucio,

Development of a Six-Month Prognostic Index in Patients With Advanced Chronic Medical Conditions: The PALIAR Score Máximo Bernabeu-Wittel, PhD, José.

Volume 26, Issue 6, Pages (February 2019)

Transcripción de la presentación:

Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy Brain Initiative (FACEHBI) study baseline results Sonia Moreno–Grau, Octavio Rodríguez-Gómez, Ángela Sanabria, Alba Pérez-Cordón, Domingo Sánchez-Ruiz, Carla Abdelnour, Sergi Valero, Isabel Hernández, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Silvia Gil, Miguel Ángel Santos- Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Marina Guitart, Anna Gailhajanet, Itziar de Rojas, Óscar Sotolongo-Grau, Susana Ruiz, Nuria Aguilera, Judith Papasey, Elvira Martín, Esther Peleja, Francisco Lomeña, Francisco Campos, Assumpta Vivas, Marta Gómez-Chiari, Miguel Ángel Tejero, Joan Giménez, Manuel Serrano-Ríos, Adelina Orellana, Lluís Tárraga, Agustín Ruiz, Mercè Boada C. Abdelnour, N. Aguilera, M. Alegret, M. Berthier, M. Boada, M. Buendia, S. Bullich, F. Campos, P. Cañabate, C. Cuevas, I. de Rojas, A. Espinosa, A. Gailhajenet, S. Diego, S. Gil, J. Giménez, R. Gismondi, M. Gómez-Chiari, M. Guitart, B. Hernández-Olasagarre, I. Hernández, M. Ibarria, A. Lafuente, F. Lomeña, E. Martín, J. Martínez, A. Mauleón, G. Monté, M. Moreno, S. Moreno-Grau, L. Núñez, A. Orellana, G. Ortega, A. Páez, A. Pancho, J. Pavía, E. Pelejà, A. Pérez-Cordon, V. Pérez-Grijalba, P. Pesini, S. Preckler, O. Rodríguez- Gómez, J. Romero, M. Rosende-Roca, A. Ruiz, S. Ruiz, A. Sanabria, D. Sánchez-Ruiz, M.A. Santos-Santos, M. Sarasa, O. Sotolongo- Grau, L. Tárraga, M.A. Tejero, M. Torres, S. Valero, L. Vargas, A. Vivas Sonia Moreno–Grau, Octavio Rodríguez-Gómez, Ángela Sanabria, Alba Pérez-Cordón, Domingo Sánchez-Ruiz, Carla Abdelnour, Sergi Valero, Isabel Hernández, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Silvia Gil, Miguel Ángel Santos-Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Marina Guitart, Anna Gailhajanet, Itziar de Rojas, Óscar Sotolongo-Grau, Susana Ruiz, Nuria Aguilera, Judith Papasey, Elvira Martín, Esther Peleja, Francisco Lomeña, Francisco Campos, Assumpta Vivas, Marta Gómez-Chiari, Miguel Ángel Tejero, Joan Giménez, Manuel Serrano-Ríos, Adelina Orellana, Lluís Tárraga, Agustín Ruiz, Mercè Boada C. Abdelnour, N. Aguilera, M. Alegret, M. Berthier, M. Boada, M. Buendia, S. Bullich, F. Campos, P. Cañabate, C. Cuevas, I. de Rojas, A. Espinosa, A. Gailhajenet, S. Diego, S. Gil, J. Giménez, R. Gismondi, M. Gómez-Chiari, M. Guitart, B. Hernández-Olasagarre, I. Hernández, M. Ibarria, A. Lafuente, F. Lomeña, E. Martín, J. Martínez, A. Mauleón, G. Monté, M. Moreno, S. Moreno-Grau, L. Núñez, A. Orellana, G. Ortega, A. Páez, A. Pancho, J. Pavía, E. Pelejà, A. Pérez-Cordon, V. Pérez-Grijalba, P. Pesini, S. Preckler, O. Rodríguez-Gómez, J. Romero, M. Rosende-Roca, A. Ruiz, S. Ruiz, A. Sanabria, D. Sánchez-Ruiz, M.A. Santos-Santos, M. Sarasa, O. Sotolongo-Grau, L. Tárraga, M.A. Tejero, M. Torres, S. Valero, L. Vargas, A. Vivas Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 14, Issue 5, Pages 634-643 (May 2018) DOI: 10.1016/j.jalz.2017.10.005 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Forest plot for the effect of APOE ε4 genotype in risk to be diagnosed with SCD. Abbreviations: ADNI, Alzheimer's Disease Neuroimaging Initiative; APOE, apolipoprotein E; CI, confidence interval; OR, odds ratio; SCD, subjective cognitive decline. For further information about Czech brain aging study, LASA, Vallecas Study, and PATH Study, see references [45], [46], [47] and [48], respectively. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2018 14, 634-643DOI: (10.1016/j.jalz.2017.10.005) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Effect of APOE allele dosage in cerebral amyloid burden for the FACEHBI cohort. Mean is represented in white. Abbreviations: APOE, apolipoprotein E; SUVR, standardized uptake value ratio. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2018 14, 634-643DOI: (10.1016/j.jalz.2017.10.005) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 Forest plot for (A) the effect of APOE ε4 and (B) the age, in amyloid burden across clinical categories. Abbreviations: AD, Alzheimer's disease; ADNI, Alzheimer's Disease Neuroimaging Initiative; APOE, apolipoprotein; EMCI, early mild cognitive impairment; FACEHBI, Fundacio ACE Healthy Brain Initiative; HC, healthy control; LMCI, late mild cognitive impairment; PET, positron emission tomography; SCD, subjective cognitive decline; SMC, subjective memory impairment. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2018 14, 634-643DOI: (10.1016/j.jalz.2017.10.005) Copyright © 2017 The Authors Terms and Conditions

Supplementary Fig. 4 Correlation between APOE allele dosage and brain amyloid burden per clinical category. Abbreviations: AD, Alzheimer's disease; ADNI, Alzheimer's Disease Neuroimaging Initiative; APOE, apolipoprotein; EMCI, early mild cognitive impairment; FACEHBI, Fundacio ACE Healthy Brain Initiative; HC, healthy control; LMCI, late mild cognitive impairment; SCD, subjective cognitive decline. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2018 14, 634-643DOI: (10.1016/j.jalz.2017.10.005) Copyright © 2017 The Authors Terms and Conditions