International Journal of Infectious Diseases Changing trends in serotypes of S. pneumoniae isolates causing invasive and non- invasive diseases in unvaccinated population in Mexico (2000-2014)  María Noemí Carnalla-Barajas, Araceli Soto-Noguerón, Miguel Angel Sánchez-Alemán, Fortino Solórzano-Santos, María Elena Velazquez-Meza, Gabriela Echániz-Aviles Francisco Márquez-Díaz, Lucila Martínez-Medina, María Elizabeth Olvera-Herrera, Maria Guadalupe Miranda-Novales, Martha Camacho-Velázquez, José Guillermo Vásquez-Rosales, Rosario Vázquez-Larios, Eduardo Rivera- Martínez, Ana María Hernández-Dueñas, Briceida López-Martínez, Sarbelio Moreno-Espinoza, Ernesto Calderón-Jaimes, Yolanda Jiménez-Tapia, José Luís Arredondo-García, Mercedes Macías-Parra, Patricia Arzate-Barbosa, Napoleón González-Saldaña, José Sifuentes-Osornio, Alfredo Ponce de León-Garduño, Ana Lilia Rolón-Montes de Oca, Rosa Areli Martínez-Gamboa, Patricia Volkow- Fernández, Patricia Cornejo-Juárez, José Manuel Feliciano-Guzmán, Ismelda López-Ovilla, Juan Manuel Barajas-Magallón, Jorge Alejandro Vázquez-Narváez, Alejandra Cendejas-Amezcua, María del Rosario Magaña-Miranda, Andrés Flores Santos, Martín Magaña- Aquino, Antonio Luévanos-Velázquez, Rayo Morfín-Otero, Eduardo Rodríguez-Noriega, Sergio Esparza-Ahumada, Guadalupe Atilano- Durán, Norma de la Re-Montaño, Martha Anchondo-Martínez, Jesús Contreras-Soto, Ana Dolores Quintero-Grijalva, Jacobo Ayala- Aguilar, Claudia E. Guajardo-Lara, Elvira Garza-González, oaquín Rincón-Zuno, Domingo Sánchez-Francia, Verónica Andrade-Almaraz, Reyna Edith Corte-Rojas, María del Socorro Gutierrez-Rodríguez, Socorro Azarell Anzurez-Gutiérrez, Juan Luis Mosqueda-Gómez, Mariana Gil-Veloz, Javier Castellanos-Martínez, Juan Carlos Tinoco-Fávila, Lorena Salcido-Gutiérrez, Rosalía Jarillo-Medina, Jessica Paola-Purizaca Bazán, Dinora Aguilar-Escobar, Ana Rosa Méndez-Cruz, Leova Pacheco-Gil, Edgardo S. Acevedo-Casarrubias, Alma Rosa González-Hernandez, María del Carmen Alvarez Molina, Manuel Ibarra-Muñiz, Paul Mora-Dominguez María Noemí Carnalla- Barajas, Araceli Soto-Noguerón, Miguel Angel Sánchez-Alemán, Fortino Solórzano-Santos, María Elena Velazquez-Meza, Gabriela Echániz-Aviles Francisco Márquez-Díaz, Lucila Martínez-Medina, María Elizabeth Olvera-Herrera, Maria Guadalupe Miranda-Novales, Martha Camacho-Velázquez, José Guillermo Vásquez-Rosales, Rosario Vázquez-Larios, Eduardo Rivera-Martínez, Ana María Hernández-Dueñas, Briceida López-Martínez, Sarbelio Moreno-Espinoza, Ernesto Calderón-Jaimes, Yolanda Jiménez-Tapia, José Luís Arredondo-García, Mercedes Macías-Parra, Patricia Arzate-Barbosa, Napoleón González-Saldaña, José Sifuentes-Osornio, Alfredo Ponce de León-Garduño, Ana Lilia Rolón-Montes de Oca, Rosa Areli Martínez-Gamboa, Patricia Volkow-Fernández, Patricia Cornejo- Juárez, José Manuel Feliciano-Guzmán, Ismelda López-Ovilla, Juan Manuel Barajas-Magallón, Jorge Alejandro Vázquez-Narváez, Alejandra Cendejas-Amezcua, María del Rosario Magaña-Miranda, Andrés Flores Santos, Martín Magaña-Aquino, Antonio Luévanos- Velázquez, Rayo Morfín-Otero, Eduardo Rodríguez-Noriega, Sergio Esparza-Ahumada, Guadalupe Atilano-Durán, Norma de la Re- Montaño, Martha Anchondo-Martínez, Jesús Contreras-Soto, Ana Dolores Quintero-Grijalva, Jacobo Ayala-Aguilar, Claudia E. Guajardo- Lara, Elvira Garza-González, oaquín Rincón-Zuno, Domingo Sánchez-Francia, Verónica Andrade-Almaraz, Reyna Edith Corte-Rojas, María del Socorro Gutierrez-Rodríguez, Socorro Azarell Anzurez-Gutiérrez, Juan Luis Mosqueda-Gómez, Mariana Gil-Veloz, Javier Castellanos-Martínez, Juan Carlos Tinoco-Fávila, Lorena Salcido-Gutiérrez, Rosalía Jarillo-Medina, Jessica Paola-Purizaca Bazán, Dinora Aguilar-Escobar, Ana Rosa Méndez-Cruz, Leova Pacheco-Gil, Edgardo S. Acevedo-Casarrubias, Alma Rosa González- Hernandez, María del Carmen Alvarez Molina, Manuel Ibarra-Muñiz, Paul Mora-Dominguez  International Journal of Infectious Diseases  Volume 58, Pages 1-7 (May 2017) DOI: 10.1016/j.ijid.2017.02.005 Copyright © 2017 The Author(s) Terms and Conditions

Figure 1 Trends of pneumococcal serotypes covered by PCV7, PCV10, PCV13 and PPV23 from 2000 to 2014. NVT=Non-vaccine types. International Journal of Infectious Diseases 2017 58, 1-7DOI: (10.1016/j.ijid.2017.02.005) Copyright © 2017 The Author(s) Terms and Conditions

Figure 2 Distribution of pneumococcal serotypes covered by PCV7, PCV10, PCV13 and PPV23 according to age groups from 2000 to 2014. NVT=Non-vaccine types; only trends with p<0.05 are shown. International Journal of Infectious Diseases 2017 58, 1-7DOI: (10.1016/j.ijid.2017.02.005) Copyright © 2017 The Author(s) Terms and Conditions

Figure 3 Pneumococcal serotype distribution according to age group before and after introduction of PCV7 in Mexico (2000-2014). *p≤0.05, **p≤0.001; VT are those included in PCV13 Others (Serotypes: 13, 20, 21, 29, 31, 34, 42, 10A, 10F, 11A, 11F, 12F, 18A, 18F, 19C, 28A, 7C, 9A, 9L, 9N, 2, 8, 38, 10B, 16F, 17F, 19B, 22F, 24F, 7B and non-typable). International Journal of Infectious Diseases 2017 58, 1-7DOI: (10.1016/j.ijid.2017.02.005) Copyright © 2017 The Author(s) Terms and Conditions