Volume 128, Issue 3, Pages 636-641 (March 2005) Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients Manuel Romero-Gómez, Maria Del Mar Viloria, Raúl J. Andrade, Javier Salmerón, Moisés Diago, Conrado M. Fernández-Rodríguez, Raquel Corpas, Marina Cruz, Lourdes Grande, Luis Vázquez, Paloma Muñoz-de-Rueda, Pilar López-Serrano, Ana Gila, María L. Gutiérrez, Celia Pérez, Angela Ruiz-Extremera, Emilio Suárez, Jesús Castillo Gastroenterology Volume 128, Issue 3, Pages 636-641 (March 2005) DOI: 10.1053/j.gastro.2004.12.049 Copyright © 2005 American Gastroenterological Association Terms and Conditions
Figure 1 Sustained response rate in patients infected by genotype 1 and segregated with respect to insulin resistance index (HOMA <2, 2–4, and >4; odds ratio, 2.43; 95% CI, 1.41–4.20; P = .004). Gastroenterology 2005 128, 636-641DOI: (10.1053/j.gastro.2004.12.049) Copyright © 2005 American Gastroenterological Association Terms and Conditions
Figure 2 Clinical evolution of insulin resistance (HOMA-IR) during and after treatment according to virological status (nonresponders, relapsers, and sustained responders). The paired t test indicated statistical significance when baseline HOMA-IR values were compared with those at the end of follow-up in sustained responders (2.55 ± 2.52 vs. 1.50 ± 0.77; P < .05). NR, nonresponders; RR, relapsers; SVR, sustained virological responders. Gastroenterology 2005 128, 636-641DOI: (10.1053/j.gastro.2004.12.049) Copyright © 2005 American Gastroenterological Association Terms and Conditions