UNIVERSIDAD DEL VALLE DE MÉXICO RECEPTORES CELULARES DR. GERARDO CANCINO BALCÁZAR DIVISIÓN DE CIENCIAS DE LA SALUD
Comunicación Celular
Receptores celulares
Comunicación Celular
Receptores unidos a proteínas G
Receptores tipo canal ionico
Receptores tipo tirosin cinasas
Receptores con actividad intrinsica
Segundos Mensajeros
AMPc
TissueHormone Inducing Rise in cAMPMetabolic Response AdiposeEpinephrine; ACTH; glucagonIncrease in hydrolysis of triglyceride; decrease in amino acid uptake LiverEpinephrine; norepinephrine; glucagonIncrease in conversion of glycogen to glucose; inhibition of synthesis of glycogen; increase in amino acid uptake; increase in gluconeogenesis (synthesis of glucose from amino acids) Ovarian follicle FSH; LHIncrease in synthesis of estrogen, progesterone Adrenal cortex ACTHIncrease in synthesis of aldosterone, cortisol Cardiac muscle cells EpinephrineIncrease in contraction rate ThyroidTSHSecretion of thyroxine Bone cellsParathyroid hormoneIncrease in resorption of calcium from bone Skeletal muscle EpinephrineConversion of glycogen to glucose IntestineEpinephrineFluid secretion KidneyVasopressinResorption of water Blood platelets Prostaglandin IInhibition of aggregation and secretion
Segundos Mensajeros
TissueHormone Inducinga Rise in IP 3 Cellular Response Pancreas (acinar cells)AcetylcholineSecretion of digestive enzymes, such as amylase and trypsinogen Parotid (salivary gland)AcetylcholineSecretion of amylase Pancreas (β cells of islets)AcetylcholineSecretion of insulin Vascular or stomach smooth muscleAcetylcholineContraction LiverVasopressinConversion of glycogen to glucose Blood plateletsThrombinAggregation, shape change, secretion of hormones Mast cellsAntigenHistamine secretion FibroblastsPeptide growth factors, such as bombesin and PDGF DNA synthesis, cell division Sea urchin eggsSpermatozoaRise of fertilization membrane
Calcio
Proteínas de señalización
Proteínas cambiadoras de GTPasas
Proteínas cinasas
Proteínas adaptadoras
Receptores Intracelulares