Response to HAART in naïve patients with a diagnosis of tuberculosis. R esults from the Spanish cohort of antiretroviral naïve patients Moreno S, Sobrino P, Caro-Murillo AM, Iribarren JA, Ramos JM, Vidal F, Navarro G, Lopez Aldeguer J, Santos I, Del Amo J and CoRIS FUNDING: ISCIII-RETIC RD06/006

Objective  To evaluate immunological, virological and clinical responses to HAART, as well as all-cause mortality, in naïve patients with a diagnosis of TB compared to subjects with another ADI or event- free individuals. Subjects & Methods  CoRIS is an multicenter cohort of naïve adults recruited in 19 Spanish hospitals:  Patients were classified according to having had TB, other ADI 6 months before HAART or being AIDS-free.  Immunological response: increase of 50 cells perx10 6 cells/l 6 months after HAART and 100 perx10 6 cells/l a year after HAART.  Virological response: percentage of subjects reaching VL below 50 copies six months or a year after HAART.  All cause mortality rates were modelled with Cox regression

Study population 1709 subjects Immunological response Virological response NS

Multivariate Cox Regression Death rates according to ADI status before HAART

 A diagnosis of TB or another ADI before starting HAART does not compromise short-term viral and immunological responses to treatment.  Subjects who started HAART and had a previous ADI had an increased mortality compared to subjects who were AIDS-free, although differences were statistically significant for ADI other than TB Conclusions

Moreno S, Sobrino P, Caro-Murillo AM, Iribarren JA, Ramos JM, Vidal F, Navarro G, Lopez Aldeguer J, Santos I, Del Amo J and CoRIS. GRUPO CoRIS: Hospital de Bellvitge: Daniel Podzamczer, Elena Ferrer, María Saumoy, Montserrat Olmo, Concepción Faz Méndez, Antonia Vila, Patricia Barragán, Carmen Peña, María del Carmen Cabellos, Ferrán Bolao, Pochita Sánchez. Hospital Universitario de Canarias: Juan Luis Gómez Sirvent, Patricia Rodríguez Fortúnez, María Remedios Alemán Valls, María del Mar Alonso Socas, Ana María López Lirola, María Inmaculada Hernández Hernández. Hospital Carlos III: Vicente Soriano, Pablo Labarga, Pablo Barreiro, José Medrano, Pablo Rivas, Dolores Herrero, Francisco Blanco, Mª Eugenia Vispo, Luz Martín Carbonero, Germán Ramirez, Mercedes de Diego. Hospital Clinic: José M. Miró, José Fernando García, Fernando Agüero, Christian Manzardo, Laura Zamora, Cristina Gil, José Luis Blanco, Felipe García-Alcaide, Esteban Martínez, Josep Mallolas, María López-Dieguez, José M. Gatell. Hospital Doce de Octubre: Rafael Rubio, Federico Pulido, Víctor Moreno Cuerda, Concepción Cepeda, Rafael Hervás. Hospital Donostia: José Antonio Iribarren, Julio Arrizabalaga, María José Aramburu, Xabier Camino, Francisco Rodríguez-Arrondo, Miguel Ángel von Wichmann, Lidia Pascual Tomé, Miguel Ángel Goenaga. Hospital General de Elche: Félix Gutiérrez, Mar Masiá, José Manuel Ramos, Sergio Padilla, Victoria Sánchez-Hellín, Enrique Bernal, Clara Escolano, Fernando Montolio, Yolanda Peral.Hospital Germans Trías i Pujol: Bonaventura Clotet, Cristina Tural, Lidia Ruiz, Cristina Miranda. Hospital Gregorio Marañón: Juan Berenguer, Juan Carlos López Bernaldo de Quirós, Pilar Miralles, Jaime Cosín Ochaíta, Matilde Sánchez Conde, Isabel Gutiérrez Cuellar, Margarita Ramírez Schacke, Belén Padilla Ortega. Hospital Joan XXIII: Francesc Vidal, Marta Sanjuan, Joaquín Peraire, Sergio Veloso, Consuelo Viladés, Miguel López-Dupla, Montserrat Olona, Montserrat Vargas. Hospital La Fe: José López Aldeguer, Marino Blanes Juliá, José Lacruz Rodrigo, Miguel Salavert, Marta Montero, Sandra Cuéllar. Hospital de la Princesa: Ignacio de los Santos, Jesús Sanz Sanz. Hospital San Pedro: José Antonio Oteo, José Ramón Blanco, Valvanera Ibarra, Luis Metola, Mercedes Sanz, Laura Pérez-Martínez. Hospital de Navarra: Julio Sola, Javier Uriz, Jesús Castiello, Jesús Reparaz, María Jesús Arriaza, Carmen Irigoyen. Hospital Parc Taulí: Ferrán Segura, María José Amengual, Eva Penelo, Gemma Navarro, Montserrat Sala, Manuel Cervantes, Valentín Pineda. Hospital Ramón y Cajal: Santiago Moreno, Antonio Antela, José Luis Casado, Fernando Dronda, Ana Moreno, María Jesús Pérez Elías, Dolores López, Carolina Gutiérrez, Beatriz Hernández, María Pumares, Paloma Martí, Lucía García San Miguel, Carmen Page Alonso. Hospital San Cecilio: Federico García García, José Hernández Quero, Alejandro Peña Monje, Leopoldo Muñoz Medina, Jorge Parra Ruiz. Hospital Son Dureta: Melchor Riera, Javier Murillas. Hospital Virgen del Rocío: Pompeyo Viciana, Manuel Leal, Luis Fernando López-Cortés, Mónica Trastoy, Rosario Mata Alcázar-Caballero. Steering committee: Juan Berenguer, Julia del Amo,Federico García, Félix Gutiérrez, Pablo Labarga, Santiago Moreno, María Ángeles Muñoz. Field work, data management and statistical analyses: Ana María Caro-Murillo, Paz Sobrino. BioBank: María Ángeles Muñoz, Milagros González Rivera, Pilar Martínez.