El método científico para una piel luminosa

Presentación del tema: "El método científico para una piel luminosa"— Transcripción de la presentación:

1 El método científico para una piel luminosa
Presentación del Sistema (Slide 1: Title Slide) Welcome to today’s presentation on Nu Skin’s innovative Tri-Phasic White System—The scientific method for brilliant skin! El método científico para una piel luminosa © 2004 Nu Skin®

2 La belleza de una Piel Clara y Luminosa
(Slide 2: The Beauty of Fair Skin) We know that in nature, delicate, translucent color allows light to reflect beautifully. Take, for example, the delicate petals of a flower, a butterfly wing, a perfect pearl, or an unblemished diamond.

3 La belleza de una Piel clara y Uniforme
(Slide 3: The Beauty of Fair, Even Skin) It’s the same with skin. An uneven tone and dark marks cause skin to look stressed, dull, or aged; whereas, a fair, even complexion lets natural beauty radiate. Understanding what causes skin to lose its natural, fair tone can help us understand how to restore a refined appearance. This will also help illustrate how Nu Skin’s new system—Tri-Phasic White—is different from other whitening lines.

4 Investigadores Líderes en el Cuidado de la Piel
(Slide 5: Leading Skin Care Researchers) To develop this system, Nu Skin worked with researchers around the world to more fully understand the pigmentation process and to identify the most effective and innovative approaches for interfering with the three phases of discoloration. In fact, we added a skin pigmentation specialist to our professional advisory board to give us world-class expertise in both the development and education of skin whitening technology and products.

5 Dr. Bryan Fuller (Slide 6: Dr. Bryan Fuller)
We are very proud to be able to bring you the expertise of Dr. Bryan Fuller, one of our newest advisory board members. Dr. Fuller will help us understand the role pigment plays in the coloration and discoloration of the skin and thoroughly explain the three phases of the pigmentation process.

6 Proceso de Pigmentación
(Slide 7: Dr. Bryan Fuller personal intro and Title Slide: The Pigmentation Process) Hello. My name is Bryan Fuller. I’m a professor of biochemistry and molecular biology at the University of Oklahoma Health Science Center, and for 30 years my interest has been endocrinology, specifically how hormones regulate pigment cell function and skin cell function. I am here to talk to you today about the biology of human skin pigmentation.

7 Proceso de Pigmentación: Tres fases
Activación: Se inicia el proceso de producción de melanina. Síntesis: la melanina es producida por los melanocitos. Expresión: la melanina es transportada a la superficie de la piel. (Slide 10: Pigmentation Process: Three Phases) So how does the whole process occur? The process of pigmentation consists of three phases: activation, synthesis, and expression. The activation phase occurs when the melanocytes, receive some sort of stimulus that causes them to go into a defensive mode and begin the melanin production process. The synthesis phase is when the melanocyte actually makes the melanin granules called melanosomes. There are actually several processes in the synthesis phase that create these packages of melanin. Finally, there is the expression phase. In this phase, the melanosomes are transferred from the melanocytes to the upper skin cell layers. After this transfer takes place, the color will eventually become visible on the surface of the skin. So, to briefly recap the three phases of the skin pigmentation process are: activation, synthesis, and expression.

8 ¿Donde empieza el proceso de pigmentación?
La parte más profunda de la epidermis (Slide 8: Where does the pigmentation process begin?) Pigment, also called melanin, is a brown-black substance that protects the body from the damaging effects of the sun’s ultraviolet radiation. The process of skin pigmentation really starts at the lower part of your epidermis. Your skin has two parts: the upper epidermis and the lower dermis. In between these two layers—the epidermis and the dermis—are found a population of cells called melanocytes.

9 QUERATINOCITOS MELANOCITO Queratinocito Transferencia Melanosoma
Melanin (Slide 8: Where does the pigmentation process begin?) Pigment, also called melanin, is a brown-black substance that protects the body from the damaging effects of the sun’s ultraviolet radiation. The process of skin pigmentation really starts at the lower part of your epidermis. Your skin has two parts: the upper epidermis and the lower dermis. In between these two layers—the epidermis and the dermis—are found a population of cells called melanocytes. Eumelanina Pheomelanina MELANOCITO Dopaquinona Tirosinase Dopa Tiraosine

10 Activación (Slide 11: Activation Phase)
Let’s look a little closer into each of these phases. First, we will discuss the activation phase.

11 Síntesis (Slide 13: Synthesis Phase)
This begins the synthesis phase of the pigmentation process.

12 Dopaquinona → Faeo ó Eu Melanina
Tirosinasa Tirosinasa Faeo-melanina (Slide 17: Dopaquinone to Phaeo or Eu Melanin) Now, once you reach the DOPAquinone stage of the reaction, the cell has two choices to make: It can either take DOPAquinone and make dark melanin, also called eu-melanin, or the melanocyte can use DOPAquinone to make a reddish/yellow melanin, called phaeo-melanin Tirosina Dopa Dopaquinona Eu-melanina

13 Faeo y Eu Melanina Faeo-melanina Dopaquinona Eu-melanina
(Slide 18: Phaeo and Eu Melanin) An easy way to understand these two forms of melanin is to look at hair color. For those of you who have black hair, the pigment cells in your scalp are making eu-melanin. And for those of you with lighter-colored hair, the pigment cells in your scalp are making phaeo-melanin.

14 Fase de Expresión : El Proceso
(Slide 21: Expression Phase: The Process) Once they are filled, melanosomes travel along the melanocyte, out into the arms of the melanocyte. I like to think of a melanocyte as a cell that has tentacles, very long tentacles. And these tentacles have a scientific name: they’re called dendrites. So the melanosomes travel out along these dendrites. When they reach the end of the dendrites, they are actually pushed out of the melanocyte and taken up by keratinocytes, which are the skin cells lying above the melanocytes in your epidermis. The keratinocytes take up these melanosomes and carry them all the way up to the surface of the skin.

15 Expresión de la Melanina a la Superficie de la Piel
Melanosoma lleno de Mancha MELANOCYTES KERATINOCYTES (Slide 22: Expression of Melanin on Skin’s Surface) We are all familiar with the fact that new skin cells travel up to the surface of our skin every day. Your skin is always replenishing or renewing itself, and it does that by taking these keratinocytes and moving them up to the surface of the skin where they die and are shed off when you take a shower or rub your skin. As the melanosomes are transferred from the melanocytes to the keratinocytes, the keratinocytes take these melanin-filled melanosomes and carry them to the surface of the skin. Melanosomes don’t move from one keratinocyte to another; rather, a melanosome is taken up by a given keratinocyte, and it stays within that keratinocyte. When that keratinocyte migrates to the surface of the skin, then you appear darker.

16 (Slide 23: Pics of different skin types)
Now, how efficient is that whole process? You actually don’t have that many melanocytes in your skin, but they’re very efficient factories. One melanocyte will actually make and distribute melanosomes to over 30 keratinocytes. Studies have been performed where scientists actually counted every melanocyte in every part of the skin. It turns out that the number of melanocytes in the face, head, and arms is higher than on the trunk and back…it’s about double the number. However, pigmentation cannot be explained based on the number of melanocytes. For example, consider the question, “Why is a black person with highly pigmented skin so dark, and why are Caucasians so light?” A lot of people used to think, “Well, they must have more pigment cells in their skin,” which would clearly explain the difference. That is not the case. The number of pigment cells, or melanocytes, in everyone’s skin, regardless of racial skin type and genetic origin, is the same for everybody. We all have the same number of pigment cells. The difference in somebody’s skin color is due to the activity of tyrosinase. Those people who have melanocytes where tyrosinase activity is very high make a lot more melanin than people who have very low tyrosinase activity. There are also some other genetic differences, for example: the ability of melanosomes to be transferred to keratinocytes. This transfer process is more efficient in some racial skin types than it is in others. For example, people with very dark skin have a more efficient transfer process than people with light skin. If you think about the differences in tyrosinase activity and in melanosome transfer, that explains all the differences in people’s skin color.

17 Proceso de Oscurecimiento de la Piel
Aunado al proceso normal de pigmentación, donde la hormona MSH inicia la la activación de la síntesis de melanina, otros factores pueden también provocar la producción de melanina (Slide 24: The Discoloration Process) So now you have an understanding of the pigmentation process. But you also know that our skin doesn’t always darken uniformly; we often have patchy areas of discoloration. As previously mentioned, your melanocytes are activated by UV radiation, hormones, and stress. These stressors can cause non-uniform discoloration. Irritantes (Contaminantes) Hormonas (Embarazo) Luz UV (Sol) Estrés

18 Activación Síntesis Expresión
(Slide 26: Pics of Activation, Synthesis, Expression) So is there anything that we can do? Is there any way for us to control this process or reset the melanocytes back to a more normal resting state? The answer is yes. There are ways that you can block the activation of a melanocyte by blocking the ability of these hormone-like compounds, including MSH, to bind its receptor on the melanocyte. If these stressors, irritants, or hormones can’t reach their receptors or bind to their receptors on the melanocyte, you will not activate the melanocyte, stopping the whole process from beginning. The other way to control pigmentation is to block or shut off the synthesis phase. And most skin lightening products on the market today contain ingredients that actually work at blocking only one of the three critical processes within the synthesis phase; they work to block the activity of tyrosinase. If tyrosinase, in an active state, is trying to take tyrosine and make melanin, these skin whitening agents get in there, bind to the enzyme, and interfere with its ability to convert tyrosine to melanin—and that’s how they work. They are basically competitive inhibitors of the enzyme. That is a standard, well-accepted method of controlling the pigmentation response. Another way to control the synthesis of pigment, is to encourage the production of the lighter form of melanin or phaeo-melanin instead of the darker form, eu-melanin. There are actually ingredients that can have this influence on the melanocyte. A novel way of controlling discoloration, is to interfere with the expression phase, and there are actually ways to do that. You are trying to minimize the transfer of melanosomes to the keratinocytes. If you can block the transfer of the melanosomes to the keratinocytes, obviously you’ll lighten the skin. This is because as the keratinocytes migrate to the surface, they’re not carrying any melanized melanosomes with them. As a result, the melanin content decreases on the surface of your skin, and the skin will become lighter. As you can see there are a variety of ways to treat hyper-pigmentation, or at least modulate pigmentation. I hope that my explanation of the pigmentation process has been helpful to you. Understanding these basics will really help you understand the technology behind Nu Skin’s Tri-Phasic White System. Activación Síntesis Expresión

19 Sistema Nu Skin® Tri-Phasic White™
El sistema para aclarar la piel más completo que hay disponible. Con Innovaciones tecnológicas de ingredientes se creó el método científico Tri-Phasic White™. (Slide 29: Tri-Phasic White System) Knowing more about the skin pigmentation process will help us all understand why the Nu Skin® Tri-Phasic White Line is the most comprehensive skin brightening system available.

20 Sistema Nu Skin® Tri-Phasic White™
Actúa en las tres fases del proceso del oscurecimiento de la piel: Activación Síntesis Expresión Oscurecimiento (Slide 30: Origin of Name) The Tri-Phasic White System is able to inhibit the three phases of discoloration with a unique, synergistic combination of whitening ingredients. Each product contributes key ingredients that inhibit the activation, synthesis, or expression of discoloration. In nature, beauty can be explained by science; in you, a translucent, luminous, brilliant complexion can be revealed by a scientific method. Activation Synthesis Expression

21 Beneficios del Sistema
System Benefits Beneficios del Sistema Reduce la apariencia de: Manchas oscuras existentes Tono disparejo de la piel Cambio de tono de la piel Previene la formación de: Nuevas manchas oscuras Cambio de tono cutáneo Mantiene: Tono uniforme de la piel Tono luminoso de la piel (Slide 32: System Benefits) This System: Reduces the appearance of existing dark spots, uneven skin tone, and discoloration; Prevents the formation of new dark spots and discoloration; and Maintains even and bright skin tones for a more brilliant complexion.

22 Estudio Clínico Estudio clínico de 12 semanas.
29 mujeres japonesas con oscurecimiento de ligero a moderado en la cara Nu Skin® Tri-Phasic White™ mostró beneficios notorios se obtuvieron al aclarar la piel en todas las participantes. Mejoría consistente y acumulativa a las 4, 8, y 12 semanas. Medición: aclarado, luminosidad, color uniforme, mejoría en la textura y mejoría en general. (Slide 33: Clinical study) In this 12-week clinical study, 29 Japanese women with mild to moderate discoloration on the face were treated with the Nu Skin® Tri-Phasic White™ System. All subjects showed significant skin brightening benefits and consistent and cumulative improvements over weeks 4, 8, and 12. The following factors were measured in this study: brightness, radiance, even color, roughness improvement, area, and overall improvement.

23 (Slide 34: Clinical Study: Performance by Clinical Grader)
Professional clinical evaluators measuring comparison to baseline scores in test subjects measured significant improvement. For example, nearly 100 percent of subjects were scored as showing improvement in skin evenness—a very remarkable outcome for the treatment of such a difficult cosmetic condition!

24 (Slide 35: Clinical Study: Subject Questionnaire Results)
In addition to data from the professional clinical graders, information was also taken from the test participants. Over 95 percent of participants identified benefits associated with use of the Tri-Phasic White™ System, with nearly 60 percent noticing whitening benefits and over 75 percent noticing brightening benefits.

25 Estudio Clínico 100% de mejoría general después de 12 semanas.
39% de mejoría en la luminosidad de la piel. 41% mejoría en la uniformidad cutánea. 28% mejoría general. (Slide 36: Clinical Study: Results Summary) The results of this clinical study are very compelling. 100 percent of participants experienced an overall improvement after 12 weeks*. The following improvements were observed by professional graders: 100% experienced overall improvement 39% improvement in skin radiance 41% improvement in skin evenness 28% overall improvement *It’s important to note that improvement did not plateau at 12 weeks. With continuous regimen usage—targeting the three phases of discoloration—users will continue to see increased benefits.

26 Blanco: Prescripción del Líder
(Slide 37: Target: Leading Prescription) As we begin to discuss the products in detail, it is important to know that as we were developing our new whitening system, we set very high standards, requiring that the final outcome be as effective as a leading prescription treatment. After extensive and comprehensive testing, we identified a combination of ingredients that not only meet, but exceed the efficacy of the prescription product. Our products, however, work effectively without the undesirable ingredients that may cause other complications.

27 Limpiador Nu Skin® Tri-Phasic White™
Beneficios: Reduce la expresión del oscurecimiento de la piel inhibiendo la transferencia del pigmento Ingrediente Clave:: Creatinina – inhibe la transferencia del pigmento al queratinocito (Slide 39: Cleanser) The creamy Tri-Phasic White™ Cleanser contains Creatinine to help block the expression phase of discoloration. Creatinine, a naturally occurring compound in the body, helps inhibit pigment expression by inhibiting the transfer of pigment to keratinocytes (skin cells) so less pigment is expressed to the surface of the skin.

28 Tonificador Nu Skin® Tri-Phasic White™
Beneficios: Reduce la expresión del oscurecimiento Minimiza la activación del oscurecimiento Ingredientes clave: Fairtrex™ – complejo de exfoliación no-ácido Carnosina – bloquea los receptores de la irritación (Slide 40: Toner) Tri-Phasic White™ Toner visibly reduces the expression of discoloration on the surface of the skin by exfoliating skin cells to help remove accumulated dark spots and discoloration; Fairtrex™ is the ingredient blend that provides this benefit. Tri-Phasic White™ Toner also minimizes the activation of the discoloration process by blocking irritation receptors from activating synthesis of discoloration; Carnosine is the ingredient that provides this benefit.

29 Nu Skin® Tri-Phasic White™ Essence
Beneficio: Inhibe la fase de síntesis de la mancha Ingrediente clave: Brightex™ – una mezcla aclarante que actúa como inhibidor de la tirosinasa (Slide 41: Essence) To target the key synthesis phase of melanin production, the Tri-Phasic White™ Essence contains our proprietary Brightex™ formulation. Unlike other ingredients designed to work on this phase of the process through a single mechanism of action, this blend works to inhibit the formation of melanin in multiple ways by targeting three critical processes of the synthesis phase. First, Brightex™ acts as a tyrosinase inhibitor to target an enzyme critical to discoloration synthesis. In addition, Brightex™ targets the chemical conversion of melanin and works to reverse this process. Brightex™ also works to encourage the production toward the lighter form: phaeo-melanin. This lighter melanin is less stable and breaks down as it works its way to the surface of the skin. As a result, less pigmentation is expressed on the surface of the skin.

30 Loción de Día Nu Skin® Tri-Phasic White™
Beneficio: Minimiza la activación del oscurecimiento Ingredientes: Hexapeptido-2 – parcialmente bloquea los receptores hormonales. Protector UVA/UVB (SPF 15) – Ayuda a absorber y reflejar la energía de los rayos solares. (Slide 42: Day Milk Lotion) The Tri-Phasic White™ Day Milk Lotion contains SPF 15 for daily protection from the UV radiation that contributes to the formation of discoloration. It also contains a whitening peptide called Hexapeptide-2 to interfere with the activation phase of discoloration. Day Milk Lotion minimizes the activation of the discoloration process. It does this by blocking the hormone receptor with Hexapeptide-2 and by preventing UV damage with SPF 15, which protects against UVA and UVB rays.

31 Crema de Noche Nu Skin® Tri-Phasic White™
Beneficio: Minimiza la activación del oscurecimiento Ingrediente clave: Diacetyl boldina – Bloquea los receptores del estrés (Slide 43: Night Treatment) Night Cream also minimizes the activation of the discoloration process. It does this by blocking the stress receptor from activating the synthesis of discoloration. Diacetyl boldine is the hero ingredient in this formula, helping to stop discoloration before it starts.

32 Tri-Phasic White Cleanser
ACTIVACION de oscurecimiento SINTESIS del oscurecimiento EXPRESION Tri-Phasic White Cleanser Creatinine Tri-Phasic White Toner Carnosine Fairtrex Tri-Phasic White Essence Brightex Tri-Phasic White Day Milk Lotion Hexapeptide-2 UVA and UVB sunscreens SPF 15 Tri-Phasic White Night Cream Diacetyl boldine (Slide 44: Chart of Ingredients and Three Phases) Unlike other whitening lines where a single hero ingredient is formulated into all products within the system, Nu Skin Tri-Phasic White™ is a system with different ingredients in each step. These ingredients work together to minimize unwanted discoloration production and to maximize skin whitening benefits.

33 Uso Día Noche Tri-Phasic White™ Cleanser Tri-Phasic White™ Toner
Tri-Phasic White™ Essence Tri-Phasic White™ Day Milk Lotion Tri-Phasic White™ Night Cream (Slide 45: Usage) By now you understand the benefits of the Tri-Phasic White™ System, but how do you use the products? We recommend you use the complete Tri-Phasic White™ System in the morning and at night, following these usage recommendations. (Refer to chart on PowerPoint slide.) We recommend using the entire Tri-Phasic White™ System for optimum results. And although it is a complete skin care system designed to target skin discoloration and meet your skin’s basic daily needs, other regimen steps and products can be easily integrated in to your Tri-Phasic White regimen to meet any secondary skin concerns such as lines, wrinkles, or firmness.

34 Vivir más y mejor (Slide 46: Live Better, Longer)
So in conclusion, as a safe and effective cosmetic alternative to the many other whitening options available today, the new Nu Skin® Tri-Phasic White™ System is another example of our “All of the Good” philosophy. As a unique and differentiated offering within a large and growing segment of the skin care industry, Nu Skin® Tri-Phasic White™ offers a tremendous sponsoring opportunity. Together, these two elements combine to make Tri-Phasic White™ yet another great tool Nu Skin offers to help you Live Better, Longer.

35 The scientific method for brilliant skin
System (Slide 54: The End) The scientific method for brilliant skin © 2004 Nu Skin®