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2 Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 2 Table 1 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10):958-967, September 3, 2009. Table 1. Frequency of EGFR Mutations.

3 Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 3 Figure 1 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10):958-967, September 3, 2009. Figure 1. Enrollment and Outcomes.

4 Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 4 Table 2 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10):958-967, September 3, 2009. Table 2. Characteristics and Treatment Responses of 217 Patients Receiving Erlotinib.

5 Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 5 Figure 2 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10):958-967, September 3, 2009. Figure 2. Kaplan-Meier Curves of Progression-free and Overall Survival.Survival curves for 217 patients with EGFR mutations who received erlotinib therapy indicate the probability of progression-free survival (Panel A) and overall survival (Panel C) among all the patients and among those who received it as either first-line therapy or second-line therapy (Panels B and D). The cumulative number of events is listed for each time point.

6 Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 6 Table 3 Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Gonzalez- Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia- Campelo, Rosario; Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Sanchez, Jose; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Molina, Miguel; Sanchez, Jose; Taron, Miquel New England Journal of Medicine. 361(10):958-967, September 3, 2009. Table 3. Multivariate Analyses of Progression-free and Overall Survival.