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Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy volunteers during a fat-enriched diet Luis Miguel Blanco-Colio, Begoña Muñoz-García, Jose Luis Martín-Ventura, Luis Antonio Alvarez-Sala, Manuela Castilla, Ana Bustamante, Rosa María Lamuela-Raventós, Juan Gómez-Gerique, Arturo Fernández-Cruz, Jesús Millán, Jesús Egido Atherosclerosis Volume 192, Issue 2, Pages (June 2007) DOI: /j.atherosclerosis Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions
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Fig. 1 NF-kappaB activation in peripheral blood mononuclear cells. A fat-enriched diet increases NF-kappaB activation in a time-dependent manner (*p<0.05 vs. day 0), and alcohol intake decreases this activation (†p<0.05 vs. control day 5). However, vodka intake did not modify the activation of NF-kappaB induced by fat-enriched diet (*p<0.05 vs. day 0). Panel A: electrophoretic mobility shift assay of nuclear proteins from PBMCs. Panel B: densitometer quantification of NF-kappaB activity in PBMCs. Results are expressed in arbitrary units (generated by a densitometer) and fold vs. day 0 at each time point. Results are the mean of all volunteers. Atherosclerosis , DOI: ( /j.atherosclerosis ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions
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Fig. 2 Changes in circulating MCP-1 after 5 days of fat-diet intake with or without ethanol beverages. Boxes represent 25th and 75th percentiles; line within boxes, median. Error bars mark 10th and 90th percentile. Values are expressed as change respect to day 0 (*p<0.05 vs. control). Atherosclerosis , DOI: ( /j.atherosclerosis ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions
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